SCHEMBL10019358

SCHEMBL10019358

CCOc1ccc(OC(=O)c2ccc3c(c2F)C(F)(F)C(F)(F)c2c-3ccc(OCC)c2F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.39
KMT2A Q03164 4/20 0.38
LMNA P02545 3/20 0.38
MAPT P10636 4/20 0.37
ALOX15 P16050 2/20 0.37
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
TP53 P04637 2/20 0.36
THRB P10828 1/20 0.36
CCNC P24863 1/20 0.34
CDK8 P49336 1/20 0.34
PARP10 Q53GL7 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
RECQL P46063 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MEN1 O00255 1/20 0.34
SCN1A P35498 1/20 0.33
SCN2A Q99250 1/20 0.33
SCN3A Q9NY46 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10019356 0.90 ALDH1A1 (0.34) KDM4EKMT2AESR1ESR2ALDH1A1
SCHEMBL10019361 0.90 MAPT (0.44) KDM4EKMT2AMAPTESR1ESR2
SCHEMBL10019670 0.90 ESR1 (0.39) KDM4EKMT2AMAPTESR1ESR2
SCHEMBL10019672 0.89 KDM4E (0.41) KDM4ELMNAMAPTTP53
SCHEMBL15257942 0.88 ALDH1A1 (0.34) KDM4EKMT2ALMNAESR1ESR2
SCHEMBL10019357 0.86 THRB (0.35) KDM4EMAPTESR1ESR2THRB
SCHEMBL10019871 0.85 KDM4E (0.41) KDM4ELMNAMAPTTP53THRB
SCHEMBL10019667 0.85 ESR1 (0.36) KDM4EKMT2ALMNAMAPTESR1
SCHEMBL10019799 0.85 KMT2A (0.43) KMT2ALMNAMAPTTP53THRB
SCHEMBL19622078 0.84 ESR1 (0.37) KDM4EKMT2ALMNAMAPTESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2669263-B1 COMPOUND CONTAINING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORP (JP) 2017-11-22 EP disclosed
US-9193908-B2 Compound having dihydrophenanthrene, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-11-24 US disclosed
US-9193908-B2 Compound having dihydrophenanthrene, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-11-24 US disclosed
US-20130240784-A1 COMPOUND HAVING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-09-19 US disclosed
US-20130240784-A1 COMPOUND HAVING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-09-19 US disclosed
WO-2012086437-A1 COMPOUND CONTAINING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY JNC株式会社 (JP) 2012-06-28 WO disclosed