Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098652 | 0.91 | NPC1 (0.38) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1100680 | 0.90 | NPC1 (0.37) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1098829 | 0.88 | NPC1 (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL1101121 | 0.81 | ALDH1A1 (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5816097 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4445959 | 0.80 | NPC1 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14577752 | 0.79 | NPC1 (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL825195 | 0.79 | MAPT (0.32) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1100373 | 0.79 | MAPT (0.34) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13367072 | 0.79 | TSHR (0.34) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232326-B2 | UV/visible light absorbers for ophthalmic lens materials | NOVARTIS AG (CH) | 2012-07-31 | — | — | US | disclosed |
| US-20120142877-A1 | UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS | NOVARTIS AG (CH) | 2012-06-07 | — | — | US | disclosed |