Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 14/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1288296 | 0.91 | PIN1 (0.38) | PIN1ALDH1A1 | |
| SCHEMBL10449200 | 0.91 | PIN1 (0.38) | PIN1ALDH1A1 | |
| SCHEMBL1288298 | 0.91 | PIN1 (0.38) | PIN1ALDH1A1 | |
| SCHEMBL1688573 | 0.89 | PIN1 (0.35) | PIN1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL10320947 | 0.88 | PIN1 (0.39) | PIN1ALDH1A1MAPT | |
| SCHEMBL10321154 | 0.88 | PIN1 (0.39) | PIN1ALDH1A1MAPT | |
| SCHEMBL10320949 | 0.88 | PIN1 (0.39) | PIN1ALDH1A1MAPT | |
| SCHEMBL10320625 | 0.88 | PIN1 (0.39) | PIN1ALDH1A1MAPT | |
| SCHEMBL1288577 | 0.83 | PIN1 (0.39) | PIN1ALDH1A1 | |
| SCHEMBL2027328 | 0.82 | PIN1 (0.35) | PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43115-E1 | Process for the manufacture of fused piperazin-2-one derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-17 | — | — | US | disclosed |
| US-RE43115-E1 | Process for the manufacture of fused piperazin-2-one derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-17 | — | — | US | disclosed |
| US-7626019-B2 | Intermediate compounds for the manufacture of fused piperazin-2-one derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7626019-B2 | Intermediate compounds for the manufacture of fused piperazin-2-one derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-20070219369-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-20 | — | — | US | disclosed |
| US-20070219369-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-20 | — | — | US | disclosed |
| US-20070213529-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213529-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213534-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213534-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213531-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213531-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213528-A1 | Process for the Manufacture of Fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213528-A1 | Process for the Manufacture of Fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213530-A1 | Intermediate Compounds for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070213530-A1 | Intermediate Compounds for the Manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-13 | — | — | US | disclosed |
| US-20070208027-A1 | Intermediate compounds for the manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-06 | — | — | US | disclosed |
| US-20070208027-A1 | Intermediate compounds for the manufacture of fused piperazin-2-one derivatives | DURAN ADIL | 2007-09-06 | — | — | US | disclosed |
| US-7238807-B2 | Hydrogenating a nitropyrimidine derivative with hydrogen in the presence of a hydrogenation catalyst, adding a copper, iron or vanadium compound to produce 7,8-dihydro-5H-pteridin-6-one derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-03 | — | — | US | disclosed |
| US-7238807-B2 | Hydrogenating a nitropyrimidine derivative with hydrogen in the presence of a hydrogenation catalyst, adding a copper, iron or vanadium compound to produce 7,8-dihydro-5H-pteridin-6-one derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219369-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 622/4885ALDH1A1 222/4885L3MBTL1 4605/4885 |
| US-20070213531-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 622/4885ALDH1A1 222/4885L3MBTL1 4605/4885 |
| US-20070213534-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 622/4885ALDH1A1 222/4885L3MBTL1 4605/4885 |
| US-20070213530-A1 | Intermediate Compounds for the Manufacture of fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 410/4885ALDH1A1 222/4885L3MBTL1 4480/4885 |
| US-20070208027-A1 | Intermediate compounds for the manufacture of fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 410/4885ALDH1A1 222/4885L3MBTL1 4480/4885 |
| US-20070213529-A1 | Process for the Manufacture of fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 622/4885ALDH1A1 222/4885L3MBTL1 4605/4885 |
| US-20070213528-A1 | Process for the Manufacture of Fused piperazin-2-one derivatives | DHFR, DPYD, DHPS | PIN1 622/4885ALDH1A1 222/4885L3MBTL1 4605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.