SCHEMBL1002578

SCHEMBL1002578

NC(=O)c1ccc(-c2ccc(C(N)=O)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.67
CA1 P00915 2/20 0.67
CA12 O43570 1/20 0.67
CA9 Q16790 1/20 0.67
CA14 Q9ULX7 1/20 0.67
MKNK1 Q9BUB5 9/20 0.61
MKNK2 Q9HBH9 9/20 0.61
PARP1 P09874 2/20 0.60
TSHR P16473 2/20 0.60
POLB P06746 1/20 0.60
CYP3A4 P08684 1/20 0.60
MAPT P10636 1/20 0.60
CYP2C19 P33261 1/20 0.60
RECQL P46063 1/20 0.60
BLM P54132 1/20 0.60
PMP22 Q01453 1/20 0.60
HSD17B10 Q99714 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
PARP10 Q53GL7 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22367342 0.92 MKNK1 (0.64) CA2CA1CA12CA9CA14
SCHEMBL27998215 0.92 MKNK1 (0.62) CA2CA1CA12CA9CA14
Terephthalamide SCHEMBL23774 0.90 PARP1 (0.71) CA2CA1CA12CA9CA14
SCHEMBL1791123 0.89 PARP10 (0.65) CA2CA1CA12CA9CA14
Terephthalamic Acid SCHEMBL16583862 0.89 PARP15 (0.65) CA2CA1CA12CA9CA14
SCHEMBL6500925 0.89 PARP15 (0.65) CA2CA1CA12CA9CA14
SCHEMBL27626919 0.89 MKNK1 (0.71) CA2CA1CA12CA9CA14
SCHEMBL3786517 0.89 PARP10 (0.65) CA2CA1CA12CA9CA14
SCHEMBL153199 0.89 MKNK1 (0.71) CA2CA1CA12CA9CA14
Benzidine SCHEMBL9460959 0.89 PARP10 (0.65) CA2CA1CA12CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773768-B1 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2018-08-22 EP claimed
US-9656103-B2 Light protecting-effective cosmetic or dermatological preparations BASF SE (DE) 2017-05-23 US claimed
EP-2363393-B1 Compounds and compositions as hedgehog pathway modulators NOVARTIS AG (CH) 2015-08-12 EP claimed
EP-1888596-B1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS GRUENENTHAL GMBH (DE) 2014-10-22 EP claimed
EP-2292625-B1 SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-12-25 EP claimed
EP-2074089-B1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2013-09-18 EP claimed
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 EP claimed
EP-1768644-B1 LIGHT PROTECTING-EFFECTIVE COSMETIC OR DERMATOLOGICAL PREPARATIONS CIBA HOLDING INC (CH) 2009-02-18 EP claimed
EP-0762437-B1 Electrical circuit protection devices comprising PTC conductive liquid crystal polymer compositions EATON CORP (US) 2003-01-22 EP claimed
EP-0696269-B1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES MONSANTO CO (US) 1999-06-30 EP claimed
US-5552531-A USED IN THE PRODUCTION OF AROMATIC AMINES, REACTING A NUCLEOPHILIC ANILINE, OR AMIDE OR AMINE WITH AN AZO COMPOUND MONSANTO COMPANY (US) 1996-09-03 US claimed
EP-0696269-A1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES MONSANTO COMPANY (US) 1996-02-14 EP claimed
US-5451702-A Process for preparing substituted aromatic amines MONSANTO COMPANY (US) 1995-09-19 US claimed
EP-0662074-A1 PROCESS FOR PREPARING P-NITROAROMATIC AMIDES AND PRODUCTS THEREOF. MONSANTO CO (US) 1995-07-12 EP claimed
EP-0641313-A1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES. MONSANTO CO (US) 1995-03-08 EP claimed
WO-1994025425-A1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES MONSANTO COMPANY (US) 1994-11-10 WO claimed
US-5331099-A Process for preparing p-nitroaromatic amides and products thereof MONSANTO COMPANY (US) 1994-07-19 US claimed
WO-1993024447-A1 PROCESS FOR PREPARING P-NITROAROMATIC AMIDES AND PRODUCTS THEREOF MONSANTO COMPANY (US) 1993-12-09 WO claimed
WO-1993024450-A1 PROCESS FOR PREPARING SUBSTITUTED AROMATIC AMINES MONSANTO COMPANY (US) 1993-12-09 WO claimed
WO-1993014062-A1 ANTHELMINTIC β-KETOAMIDES THE UPJOHN COMPANY (US) 1993-07-22 WO claimed