Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10027311 | 0.85 | MAPT (0.36) | HSD17B10ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL17808787 | 0.83 | ACVR1 (0.48) | HSD17B10ALDH1A1KDM4EHPGDHTT | |
| SCHEMBL17808853 | 0.81 | KDM4E (0.39) | HSD17B10ALDH1A1KDM4EHPGDHTT | |
| SCHEMBL17808907 | 0.78 | CYP2C9 (0.43) | HSD17B10ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL10027310 | 0.77 | ALDH1A1 (0.35) | HSD17B10ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL19361118 | 0.73 | AURKA (0.36) | HSD17B10TP53MAPTLMNA | |
| SCHEMBL19365017 | 0.72 | KDM5A (0.37) | ALDH1A1KDM4EHPGDTP53MAPT | |
| SCHEMBL17808847 | 0.72 | KDM4E (0.60) | HSD17B10ALDH1A1KDM4EHPGDHTT | |
| SCHEMBL17808732 | 0.71 | MAPT (0.36) | ALDH1A1KDM4EHPGDHTTTP53 | |
| SCHEMBL10027189 | 0.71 | LMNA (0.34) | HSD17B10TP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |