Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903315 | 0.75 | CHRM2 (0.58) | MEN1KMT2ACHRM2CHRM4CHRM5 | |
| SCHEMBL21067414 | 0.73 | KMT2A (0.55) | MEN1KMT2ATP53ALDH1A1POLB | |
| SCHEMBL19481502 | 0.73 | CHRM2 (0.56) | MEN1KMT2ACHRM2CHRM4CHRM5 | |
| SCHEMBL3180066 | 0.72 | CHRM2 (0.47) | TAAR1MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL672407 | 0.72 | IDO1 (0.62) | TAAR1CHRM2CYP2C9IDO1PNMT | |
| SCHEMBL29519238 | 0.72 | IDO1 (0.62) | TAAR1CHRM2CYP2C9IDO1PNMT | |
| SCHEMBL9687484 | 0.71 | MAPT (0.44) | MEN1KMT2ACHRM2CHRM4CHRM5 | |
| SCHEMBL11848084 | 0.71 | CNR2 (0.51) | TAAR1TP53MAPTSMN1; SMN2CNR2 | |
| SCHEMBL4494660 | 0.71 | HPGD (0.49) | TAAR1MEN1KMT2ACHRM2CHRM4 | |
| Water SCHEMBL9667780 | 0.71 | CHRM2 (0.45) | TAAR1MEN1KMT2ACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN, INC. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, METAP1, ACER2 | TAAR1 2610/4885ADORA2A 555/4885ADORA1 1262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.