Sugi Predict

Sugi Predict / Targets / ACER2

ACER2

Alkaline ceramidase 2 · Q5QJU3 · ACER2 on Sugi Atlas →

3,878 patent compounds predicted against ACER2, 2,859 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL360960 SCHEMBL360960 1.00 1/20
SCHEMBL611869 SCHEMBL611869 1.00 1/20
SCHEMBL4234738 SCHEMBL4234738 1.00 1/20
SCHEMBL4239949 SCHEMBL4239949 1.00 1/20
SCHEMBL4539693 SCHEMBL4539693 0.73 1/20
SCHEMBL4139305 SCHEMBL4139305 0.72 1/20
SCHEMBL4139311 SCHEMBL4139311 0.72 1/20
SCHEMBL4183115 SCHEMBL4183115 0.72 1/20
Stearic Acid Stearic Acid (SCHEMBL2369752) 0.69 1/20
Stearic Acid Stearic Acid (SCHEMBL2369756) 0.69 1/20
Decanoic Acid Decanoic Acid (SCHEMBL2370921) 0.69 1/20
Decanoic Acid Decanoic Acid (SCHEMBL2370923) 0.69 1/20
SCHEMBL4539691 SCHEMBL4539691 0.68 1/20
SCHEMBL4786264 SCHEMBL4786264 0.66 1/20
SCHEMBL2167814 SCHEMBL2167814 0.63 1/20
SCHEMBL4865267 SCHEMBL4865267 0.62 1/20
SCHEMBL4865275 SCHEMBL4865275 0.62 1/20
SCHEMBL4866142 SCHEMBL4866142 0.62 1/20
SCHEMBL4866148 SCHEMBL4866148 0.62 1/20
SCHEMBL1127067 SCHEMBL1127067 0.61 1/20

Clinical trials — most relevant to ACER2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Evaluation of Statin Mechanism Preventing Cardiovascular Disease by Post-hoc Analysis of Treating to New Targets Study PHASE4COMPLETED
Angiotensin II Blockade for Chronic Allograft Nephropathy PHASE4COMPLETED
Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial PHASE2/PHASE3UNKNOWN
Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension PHASE3COMPLETED
Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications PHASE1UNKNOWN
Study of Inherited Changes of Receptors Located on Blood Vessels PHASE1COMPLETED
Study of the Mechanisms of Asthma PHASE1COMPLETED
Expression and Function of the Renin-Angiotensin System in the Esophagus EARLY_PHASE1COMPLETED
ACE2 Gender Differences in Stroke With COVID-19 nanCOMPLETED
Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung Disease nanNOT_YET_RECRUITING
Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK) nanCOMPLETED
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE) nanRECRUITING
The Effect of RAAS Blockers on ACE2 Levels nanCOMPLETED
Biomarker for Farber Disease (BioFarber) nanWITHDRAWN
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy nanCOMPLETED
Association of Circulating ACE2 Levels With COVID-19 nanCOMPLETED
Counter-Regulatory Hormonal and Stress Systems in Patients With COVID-19 nanCOMPLETED
Markers in Acute Pancreatitis-1 nanCOMPLETED
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome nanUNKNOWN
Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease nanRECRUITING
Immunogenicity Against SARS-CoV-2 in COVID-19 Close Contacts nanUNKNOWN
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR) nanCOMPLETED
Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19). nanCOMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Characterizing a 5P-Linked BHR Susceptibility Locus nanCOMPLETED
Studying Lipids as Potential Biomarkers in Patients With Fabry Disease nanCOMPLETED
Family Blood Pressure Program - HyperGEN nanCOMPLETED
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
Genetic and Immunologic Basis of COVID-19 Infection nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ACER2 binder may also engage these)

ProteinNameSimilarity
Q8VD53 — 1.000 Q8VD53 →
Q9NUN7 — 0.962 Q9NUN7 →
Q9D099 — 0.959 Q9D099 →
Q9D1N4 — 0.957 Q9D1N4 →
Q6TCH7 — 0.952 Q6TCH7 →
Q6IQ69 — 0.951 Q6IQ69 →
Q6TCG8 — 0.949 Q6TCG8 →
Q803C9 — 0.946 Q803C9 →
Q5ZM65 — 0.944 Q5ZM65 →
PTDSS1 Phosphatidylserine synthase 1 0.943 landscape →
Q99LH2 — 0.942 Q99LH2 →
P59266 — 0.942 P59266 →
Q5PQL5 — 0.942 Q5PQL5 →
Q865K8 — 0.940 Q865K8 →
B1H3H9 — 0.938 B1H3H9 →
Q00576 — 0.938 Q00576 →
Q2KHY9 — 0.938 Q2KHY9 →
Q10PI5 — 0.937 Q10PI5 →
Q86WK9 — 0.937 Q86WK9 →
Q8CIF6 — 0.937 Q8CIF6 →
Q8NBJ9 — 0.936 Q8NBJ9 →
D3ZEH5 — 0.936 D3ZEH5 →
Q0JR55 — 0.935 Q0JR55 →
Q9DCU0 — 0.935 Q9DCU0 →
Q5RBJ7 — 0.934 Q5RBJ7 →
Q9BZW5 — 0.933 Q9BZW5 →
Q8N6M3 — 0.933 Q8N6M3 →
Q8BWB6 — 0.933 Q8BWB6 →
A6QL84 — 0.932 A6QL84 →
Q80ZE4 — 0.932 Q80ZE4 →