SCHEMBL10028765

SCHEMBL10028765

Cc1cc(Br)cc(C(=O)NC(C)(C)C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
PDE4B Q07343 4/20 0.35
TRPV1 Q8NER1 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
F10 P00742 3/20 0.34
OPRL1 P41146 1/20 0.34
F2 P00734 1/20 0.34
KLKB1 P03952 1/20 0.33
F9 P00740 1/20 0.33
TP53 P04637 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16622516 0.94 KDM4E (0.37) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL10028780 0.93 KDM4E (0.37) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL10028771 0.93 KDM4E (0.37) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL782214 0.92 CARM1 (0.38) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL10028761 0.92 KDM4E (0.37) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL15244619 0.91 PDE4B (0.40) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL31059975 0.90 F10 (0.40) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL12911649 0.89 PDE4B (0.36) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL782481 0.89 DHODH (0.36) DHODHKDM4EMEN1ALDH1A1MAPT
SCHEMBL10028757 0.89 DHODH (0.36) DHODHKDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 US disclosed
US-8735431-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-05-27 US disclosed
US-8735431-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-05-27 US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP DHODH 2787/4885KDM4E 1149/4885MEN1 2606/4885
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS DHODH 2032/4885KDM4E 372/4885MEN1 4165/4885
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties AADAC, ANTXR2, ACHE DHODH 2657/4885KDM4E 1573/4885MEN1 2817/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 DHODH 3666/4885KDM4E 2422/4885MEN1 3876/4885
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS DHODH 2064/4885KDM4E 193/4885MEN1 3992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.