SCHEMBL10030699

SCHEMBL10030699

CNc1ccc(NC(=O)c2ccc(C(C)=O)cc2)c(O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.49
POLB P06746 2/20 0.48
MAPT P10636 4/20 0.47
MEN1 O00255 2/20 0.47
GAA P10253 1/20 0.47
HDAC1 Q13547 3/20 0.45
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
PRKCI P41743 1/20 0.44
HDAC2 Q92769 2/20 0.44
HDAC3 O15379 1/20 0.44
NCOR2 Q9Y618 1/20 0.44
RXFP1 Q9HBX9 1/20 0.43
APOBEC3G Q9HC16 1/20 0.43
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
MAPK1 P28482 1/20 0.43
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10030655 0.89 HDAC1 (0.53) KMT2APOLBMAPTHDAC1NPC1
SCHEMBL13925817 0.88 NPC1 (0.57) KMT2AMAPTMEN1GAANPC1
SCHEMBL10030653 0.87 KMT2A (0.51) KMT2APOLBMAPTMEN1GAA
SCHEMBL10030689 0.84 MAPT (0.57) KMT2APOLBMAPTMEN1HDAC1
SCHEMBL10030691 0.83 KCNMA1 (0.48) KMT2APOLBMAPTMEN1HDAC1
SCHEMBL13986877 0.81 KCNMA1 (0.47) KMT2APOLBMAPTMEN1HDAC1
SCHEMBL1108320 0.81 HDAC1 (0.48) KMT2APOLBHDAC1NPC1RAB9A
SCHEMBL1108313 0.81 HPGD (0.49) KMT2APOLBMAPTHDAC1NPC1
SCHEMBL10000830 0.80 KMT2A (0.45) KMT2APOLBMAPTMEN1HDAC1
SCHEMBL8978050 0.79 KMT2A (0.61) KMT2APOLBMAPTMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2191067-B1 PAPER COMPRISING POLYBENZAZOLE OR PRECURSOR THEREOF TEIJIN ARAMID BV (NL) 2012-06-20 EP disclosed
US-20110083820-A1 PAPER COMPRISING POLYBENZAZOLE OR PRECURSOR THEREOF TEIJIN ARAMID B.V. (NL) 2011-04-14 US disclosed
US-20110083820-A1 PAPER COMPRISING POLYBENZAZOLE OR PRECURSOR THEREOF TEIJIN ARAMID B.V. (NL) 2011-04-14 US disclosed
US-20100121017-A1 POLYBENZAZOLES AND POLYBENZAZOLE PRECURSORS TIEJIN ARAMID B.V. (NL) 2010-05-13 US disclosed
US-20100121017-A1 POLYBENZAZOLES AND POLYBENZAZOLE PRECURSORS TIEJIN ARAMID B.V. (NL) 2010-05-13 US disclosed
WO-2009033983-A1 PAPER COMPRISING POLYBENZAZOLE OR PRECURSOR THEREOF TEIJIN ARAMID B.V. (NL) 2009-03-19 WO disclosed
WO-2008131907-A1 POLYBENZAZOLES AND POLYBENZAZOLE PRECURSORS TEIJIN ARAMID B.V. (NL) 2008-11-06 WO disclosed