Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506317 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBHSD17B10LMNAALDH1A1 | |
| SCHEMBL8544348 | 0.84 | USP2 (0.55) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL2350382 | 0.84 | AR (0.57) | ARLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL16272034 | 0.82 | CYP1A2 (0.44) | ARSMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL12840659 | 0.81 | L3MBTL1 (0.61) | SMN1; SMN2POLBHSD17B10LMNAALDH1A1 | |
| SCHEMBL8088577 | 0.81 | L3MBTL1 (0.44) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL15391794 | 0.81 | SMN1; SMN2 (0.70) | SMN1; SMN2POLBHSD17B10LMNAALDH1A1 | |
| SCHEMBL5317080 | 0.80 | L3MBTL1 (0.68) | SMN1; SMN2POLBHSD17B10LMNAALDH1A1 | |
| SCHEMBL13730248 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBHSD17B10LMNAALDH1A1 | |
| SCHEMBL23912992 | 0.79 | LTA4H (0.53) | SMN1; SMN2LMNAKMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475634-B1 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2017-05-24 | — | — | EP | disclosed |
| US-8471039-B2 | Process for the preparation of indoline derivatives and their intermediates thereof | SANDOZ AG (CH) | 2013-06-25 | — | — | US | disclosed |
| US-8471039-B2 | Process for the preparation of indoline derivatives and their intermediates thereof | SANDOZ AG (CH) | 2013-06-25 | — | — | US | disclosed |
| US-20120165548-A1 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF | SANDOZ AG (IN) | 2012-06-28 | — | — | US | disclosed |
| US-20120165548-A1 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF | SANDOZ AG (IN) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165548-A1 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF | PIR, CYP3A4, CYP4A11 | AR 1535/4885SMN1; SMN2 3141/4885POLB 2343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.