Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 2/20 | 0.37 |
| ▸ | POR | P16435 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8474486 | 0.85 | METAP1 (0.44) | METAP1ACHEPARP10PARP1MAOA | |
| SCHEMBL1985601 | 0.77 | PARP10 (0.43) | METAP1PARP10PARP1CA1CA2 | |
| SCHEMBL1986946 | 0.77 | PARP1 (0.43) | ACHEPARP10PARP1HTTALDH1A1 | |
| SCHEMBL30759524 | 0.77 | PARP10 (0.43) | METAP1PARP10PARP1CA1CA2 | |
| SCHEMBL21311949 | 0.74 | METAP1 (0.39) | METAP1ACHEPARP10PARP1KDM4E | |
| SCHEMBL22271438 | 0.74 | ACHE (0.59) | METAP1ACHEPARP10PARP1MAOA | |
| SCHEMBL30465799 | 0.74 | PBRM1 (0.59) | METAP1ACHEPARP10PARP1MAOA | |
| SCHEMBL354988 | 0.74 | PBRM1 (0.59) | METAP1ACHEPARP10PARP1MAOA | |
| SCHEMBL1986133 | 0.73 | PARP1 (0.47) | PARP10PARP1MAOAMAOBATM | |
| SCHEMBL402071 | 0.73 | METAP1 (0.42) | METAP1ACHEPARP10PARP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG GENGLIANG (CN) | 2014-10-02 | — | — | US | disclosed |
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG GENGLIANG (CN) | 2014-10-02 | — | — | US | disclosed |
| EP-2423213-B1 | PREPARATION AND USE OF NOVEL ANTIBIOTIC, ANTICANCER COMPOUNDS AND DERIVATIVES THEREOF | YANG GENGLIANG (CN) | 2014-01-08 | — | — | EP | disclosed |
| EP-2423213-A1 | PREPARATION AND USE OF NOVEL ANTIBIOTIC, ANTICANCER COMPOUNDS AND DERIVATIVES THEREOF | Yang, Gengliang (CN) | 2012-02-29 | — | — | EP | disclosed |
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG, Gengliang (CN) | 2012-02-09 | — | — | US | disclosed |
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG, Gengliang (CN) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | MRPL21, NRDC, SOST | METAP1 3038/4885ACHE 2202/4885PARP10 4230/4885 |
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | MRPL21, MCL1, MYC | METAP1 999/4885ACHE 1217/4885PARP10 3668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.