Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055760 | 0.83 | LMNA (0.45) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL1003821 | 0.80 | PKM (0.36) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL1026907 | 0.65 | LMNA (0.47) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL19227012 | 0.65 | PKM (0.41) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL17640901 | 0.65 | PKM (0.45) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL17629417 | 0.63 | PKM (0.43) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL1061028 | 0.61 | LMNA (0.42) | PKMKDM4EALDH1A1POLBTSHR | |
| SCHEMBL17629670 | 0.61 | KDM4E (0.47) | PKMKDM4EALDH1A1POLBRAB9A | |
| SCHEMBL253364 | 0.60 | TSHR (0.43) | PKMKDM4EALDH1A1TSHRHPGD | |
| SCHEMBL9632069 | 0.60 | GLA (0.56) | PKMALDH1A1RAB9AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257169-B1 | TETRAHYDROTHIENO PYRIDINES | MERCK SHARP & DOHME (US) | 2013-06-05 | — | — | EP | disclosed |
| US-8445680-B2 | Tetrahydrothieno pyridines | MERCK SHARP & DOHME CORP. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110009425-A1 | TETRAHYDROTHIENO PYRIDINES | MERCK SHARP & DOHME LLC | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009425-A1 | TETRAHYDROTHIENO PYRIDINES | HIF1AN, HIF1A, EGLN3 | PKM 968/4885KDM4E 272/4885ALDH1A1 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.