Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395761 | 0.87 | MEN1 (0.56) | MAPTALDH1A1SIRT6POLBMEN1 | |
| SCHEMBL12240580 | 0.80 | SIRT6 (0.74) | MAPTALDH1A1SIRT6ACHEHSD17B10 | |
| SCHEMBL14810722 | 0.78 | QDPR (0.58) | SIRT6POLBLMNA | |
| SCHEMBL27945231 | 0.74 | KDM4E (0.41) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14131758 | 0.73 | SIRT6 (0.48) | MAPTALDH1A1SIRT6POLBMEN1 | |
| SCHEMBL7292646 | 0.73 | MAPT (0.48) | MAPTALDH1A1SIRT6POLBMEN1 | |
| SCHEMBL3033121 | 0.73 | SIRT6 (0.45) | MAPTALDH1A1SIRT6POLBMEN1 | |
| SCHEMBL628918 | 0.73 | ACHE (0.86) | MAPTALDH1A1ACHEHSD17B10POLB | |
| SCHEMBL14587404 | 0.72 | SLC6A4 (0.39) | MAPTALDH1A1SIRT6ACHEHSD17B10 | |
| SCHEMBL11549718 | 0.72 | POLB (0.71) | MAPTALDH1A1SIRT6ACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053606-A1 | ARYLAMINOHETEROCYCLIC CARBOXAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2012-04-26 | — | — | WO | disclosed |