SCHEMBL10036060

SCHEMBL10036060

CCN1C(=O)/C(=C2/Sc3ccccc3N2CC)SC1=S

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 16/20 1.00
▸ KMT2A Q03164 16/20 1.00
▸ SMN1; SMN2 Q16637 3/20 0.81
▸ POLB P06746 4/20 0.80
▸ MAPT P10636 7/20 0.71
▸ MMP13 P45452 2/20 0.71
▸ CASP1 P29466 2/20 0.65
▸ HSD17B10 Q99714 2/20 0.65
▸ LMNA P02545 1/20 0.65
▸ HPGD P15428 1/20 0.65
▸ ALOX15 P16050 1/20 0.65
▸ ALOX12 P18054 1/20 0.65
▸ CASP7 P55210 1/20 0.65
▸ ALDH1A1 P00352 5/20 0.64
▸ TDP1 Q9NUW8 4/20 0.64
▸ GFER P55789 1/20 0.64
▸ NPSR1 Q6W5P4 3/20 0.62
▸ NPC1 O15118 1/20 0.58
▸ MAPK1 P28482 1/20 0.57
▸ L3MBTL1 Q9Y468 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8887899 1.00 MEN1 (1.00) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL7019338 1.00 MEN1 (1.00) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL11278635 0.90 MEN1 (1.00) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL11555123 0.90 MEN1 (1.00) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL2333246 0.89 MEN1 (0.81) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL15995453 0.89 MEN1 (0.81) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL2333243 0.89 MEN1 (0.81) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL9191085 0.89 MEN1 (0.80) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL9191082 0.89 MEN1 (0.80) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL194201 0.88 MEN1 (0.78) MEN1KMT2ASMN1; SMN2POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9764046-B2 Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method CANON KABUSHIKI KAISHA (JP) 2017-09-19 — — US disclosed
US-9764046-B2 Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method CANON KABUSHIKI KAISHA (JP) 2017-09-19 — — US disclosed
US-20150139908-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD CANON KK (JP) 2015-05-21 — — US disclosed
US-20150139908-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD CANON KK (JP) 2015-05-21 — — US disclosed
US-20120035187-A1 ANTI-NEURODEGENERATIVE DISEASE AGENT KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2012-02-09 — — US disclosed
US-20120035187-A1 ANTI-NEURODEGENERATIVE DISEASE AGENT KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2012-02-09 — — US disclosed
US-20110236310-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD CANON KABUSHIKI KAISHA (JP) 2011-09-29 — — US disclosed
US-20110236310-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD CANON KABUSHIKI KAISHA (JP) 2011-09-29 — — US disclosed
US-7335466-B2 Silver salt photothermographic dry imaging material, image recording method and image forming method for the same KONICA MINOLTA HOLDINGS, INC. (JP) 2008-02-26 — — US disclosed
US-7335466-B2 Silver salt photothermographic dry imaging material, image recording method and image forming method for the same KONICA MINOLTA HOLDINGS, INC. (JP) 2008-02-26 — — US disclosed
US-7157219-B2 Photothermographic materials containing silver halide sensitized with combination of compounds EASTMAN KODAK COMPANY (US) 2007-01-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110236310-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD ALDH1A2, PDE6C, CHAT MEN1 2132/4885KMT2A 3911/4885SMN1; SMN2 3742/4885
US-20120035187-A1 ANTI-NEURODEGENERATIVE DISEASE AGENT SNCA, PSEN1, CDR2 MEN1 2218/4885KMT2A 2624/4885SMN1; SMN2 12/4885
US-20150139908-A1 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD ALDH1A2, PDE6C, CHAT MEN1 2132/4885KMT2A 3911/4885SMN1; SMN2 3742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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