Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TARDBP | Q13148 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036510 | 0.96 | SIGMAR1 (0.52) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL10036512 | 0.83 | SIGMAR1 (0.47) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL10036509 | 0.80 | SIGMAR1 (0.49) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL10067900 | 0.79 | HSD17B10 (0.57) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL7915892 | 0.79 | HSD17B10 (0.57) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL7912695 | 0.78 | SIGMAR1 (0.49) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL12227662 | 0.77 | HSD17B10 (0.51) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL7909005 | 0.76 | SIGMAR1 (0.53) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL7919690 | 0.76 | HSD17B10 (0.56) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 | |
| SCHEMBL7842968 | 0.75 | SIGMAR1 (0.70) | HSD17B10KMT2ATARDBPSIGMAR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041025-A1 | Dihydrolipoic Acid Derivatives Comprising Nitric Oxide and Therapeutic Uses Thereof | CARMEL BIOSCIENCES, INC. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041025-A1 | Dihydrolipoic Acid Derivatives Comprising Nitric Oxide and Therapeutic Uses Thereof | DLD, LDLR, ALOX15 | HSD17B10 281/4885KMT2A 4093/4885TARDBP 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.