SCHEMBL10036558

SCHEMBL10036558

O=C(Cl)c1cc(COCl)cc(COCl)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLRA1 P23415 1/20 0.41
PTPRC P08575 2/20 0.39
PTPN1 P18031 2/20 0.39
PTPRF P10586 1/20 0.39
MRGPRX4 Q96LA9 10/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
NPC1 O15118 1/20 0.33
MITF O75030 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
XBP1 P17861 1/20 0.33
NFKB1 P19838 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PRSS1 P07477 1/20 0.32
PRSS2 P07478 1/20 0.32
PRSS3 P35030 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4572223 0.96 GLRA1 (0.41) GLRA1PTPRCPTPN1PTPRFMRGPRX4
SCHEMBL12569862 0.88 GLRA1 (0.38) GLRA1PTPRCPTPN1PTPRFMRGPRX4
SCHEMBL10042217 0.87 GLRA1 (0.37) GLRA1PTPRCPTPN1PTPRFMRGPRX4
SCHEMBL11932624 0.87 GLRA1 (0.37) GLRA1PTPRCPTPN1PTPRFMRGPRX4
SCHEMBL13234298 0.82 RXRA (0.38) GLRA1MRGPRX4SMN1; SMN2
SCHEMBL2734757 0.81 CYP4F2 (0.43) GLRA1MEN1KMT2ANPC1TP53
SCHEMBL28026974 0.81 GLRA1 (0.41) GLRA1PTPRCPTPN1PTPRFMRGPRX4
SCHEMBL278656 0.80 MRGPRX4 (0.50) MRGPRX4MEN1KMT2ANPC1MITF
SCHEMBL3864925 0.79 CA12 (0.41) GLRA1ALDH1A1
SCHEMBL13199238 0.79 MRGPRX4 (0.40) GLRA1MRGPRX4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120241373-A1 COMPOSITE MEMBRANES AND METHODS OF PREPARATION THEREOF INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-09-27 US disclosed
US-20120012527-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2012-01-19 US disclosed
US-20100216899-A1 POLYAMIDE MEMBRANES WITH FLUOROALCOHOL FUNCTIONALITY INTERNATIONAL BUSINESS MACHINES CORPORATION 2010-08-26 US disclosed
WO-2010096565-A1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-08-26 WO disclosed
WO-2010096563-A1 POLYAMIDE MEMBRANES WITH FLUOROALCOHOL FUNCTIONALITY INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-08-26 WO disclosed
US-20100216967-A1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-08-26 US disclosed