Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.71 |
| ▸ | OGFRL1 | Q5TC84 | 14/20 | 0.71 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158960 | 1.00 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL4765365 | 0.93 | OPRM1 (0.63) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL681595 | 0.88 | OPRM1 (0.74) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Citric Acid SCHEMBL381145 | 0.87 | OPRM1 (0.58) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL13805850 | 0.87 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL380587 | 0.84 | OPRM1 (0.72) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL13805841 | 0.84 | OPRM1 (0.50) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL380074 | 0.83 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL12918431 | 0.83 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL1304169 | 0.82 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170313703-A1 | Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine Compounds | GRUENENTHAL GMBH (DE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313703-A1 | Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine Compounds | GRUENENTHAL GMBH (DE) | 2017-11-02 | — | — | US | disclosed |
| US-20160159787-A1 | Cis-tetrahydro-spiro(cyclohexane-1, 1' -pyrido[3,4-b]indole)-4-amine Compounds | GRUENENTHAL GMBH (DE) | 2016-06-09 | — | — | US | disclosed |
| US-20160159787-A1 | Cis-tetrahydro-spiro(cyclohexane-1, 1' -pyrido[3,4-b]indole)-4-amine Compounds | GRUENENTHAL GMBH (DE) | 2016-06-09 | — | — | US | disclosed |
| EP-2598503-B1 | CIS-TETRAHYDRO-SPIRO(CYCLOHEXAN-1,1'-PYRIDO[3,4-B]INDOL)-4-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012013343-A1 | CIS-TETRAHYDROSPIRO(CYCLOHEXANE-1,1'-PYRIDO[3,4-B]INDOL)-4-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2012-02-02 | — | — | WO | disclosed |
| US-20120029006-A1 | Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds | GRUENENTHAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
| US-20120029006-A1 | Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds | GRUENENTHAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313703-A1 | Cis-tetrahydro-spiro(cyclohexane-1,1?-pyrido[3,4-b]indole)-4-amine Compounds | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OGFRL1 5/4885OPRL1 1/4885 |
| US-20160159787-A1 | Cis-tetrahydro-spiro(cyclohexane-1, 1' -pyrido[3,4-b]indole)-4-amine Compounds | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OGFRL1 5/4885OPRL1 1/4885 |
| US-20120029006-A1 | Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OGFRL1 5/4885OPRL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.