Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.72 |
| ▸ | OGFRL1 | Q5TC84 | 13/20 | 0.72 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL381361 | 0.87 | OPRM1 (0.58) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL682350 | 0.87 | OPRM1 (0.73) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL13805860 | 0.85 | OPRM1 (0.52) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL158960 | 0.84 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL10038876 | 0.84 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL380515 | 0.84 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL4762082 | 0.82 | OPRM1 (0.77) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL4765365 | 0.81 | OPRM1 (0.63) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL10051541 | 0.75 | OPRM1 (0.67) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL10051540 | 0.75 | OPRM1 (0.67) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150342929-A1 | Mixed ORL1/mu-agonists for the Treatment of Pain | GRUENENTHAL GMBH (DE) | 2015-12-03 | — | — | US | claimed |
| US-20140171466-A1 | PAIN MANAGEMENT IN SICKLE CELL ANEMIA | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-06-19 | — | — | US | claimed |
| EP-2206498-B9 | Mixed ORL1/[mu] agonists for treating pain | GRUENENTHAL GMBH (DE) | 2012-04-18 | — | — | EP | claimed |
| EP-2206498-B1 | Mixed ORL1/[mu] agonists for treating pain | GRUENENTHAL GMBH (DE) | 2012-01-25 | — | — | EP | claimed |
| US-20110053970-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2011-03-03 | — | — | US | claimed |
| EP-2081571-B1 | MIXED ORL 1/µ AGONISTS FOR TREATING PAIN | GRUENENTHAL GMBH (DE) | 2010-08-25 | — | — | EP | claimed |
| US-20080221141-A1 | 1 1,1-(3-dimethylamino-3-phenylpentamethylene)-1,3,4,9-tetrahydropyrano[3,4-b]indole; affinity to mu -opioid receptor | GRUENENTHAL GMBH (DE) | 2008-09-11 | — | — | US | claimed |
| EP-1725567-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | GRUENENTHAL GMBH (DE) | 2008-03-26 | — | — | EP | claimed |
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2016-09-22 | — | — | US | disclosed |
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2016-09-22 | — | — | US | disclosed |
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2016-09-22 | — | — | US | disclosed |
| US-20150342929-A1 | Mixed ORL1/mu-agonists for the Treatment of Pain | GRUENENTHAL GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-20150342929-A1 | Mixed ORL1/mu-agonists for the Treatment of Pain | GRUENENTHAL GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-20140303125-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2014-10-09 | — | — | US | disclosed |
| US-20080125475-A1 | Mixed ORL1/mu-agonists for the treatment of pain | GRUNENTHAL GMBH (DE) | 2008-05-29 | — | — | US | disclosed |
| US-20080125475-A1 | Mixed ORL1/mu-agonists for the treatment of pain | GRUNENTHAL GMBH (DE) | 2008-05-29 | — | — | US | disclosed |
| WO-2008040481-A1 | MIXED ORL 1/μ AGONISTS FOR TREATING PAIN | Grünenthal GmbH (DE) | 2008-04-10 | — | — | WO | disclosed |
| EP-1725567-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | GRUENENTHAL GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| US-7332519-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2008-02-19 | — | — | US | disclosed |
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221141-A1 | 1 1,1-(3-dimethylamino-3-phenylpentamethylene)-1,3,4,9-tetrahydropyrano[3,4-b]indole; affinity to mu -opioid receptor | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885OGFRL1 34/4885OPRL1 4/4885 |
| US-20110053970-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | TACR2, OPRK1, OPRD1 | OPRM1 8/4885OGFRL1 307/4885OPRL1 12/4885 |
| US-20080125475-A1 | Mixed ORL1/mu-agonists for the treatment of pain | OPRL1, OPRM1, OPRK1 | OPRM1 2/4885OGFRL1 5/4885OPRL1 1/4885 |
| US-20140303125-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | TACR2, OPRK1, OPRD1 | OPRM1 8/4885OGFRL1 307/4885OPRL1 12/4885 |
| US-20140171466-A1 | PAIN MANAGEMENT IN SICKLE CELL ANEMIA | OPRL1, OPRM1, OPRK1 | OPRM1 2/4885OGFRL1 68/4885OPRL1 1/4885 |
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | TACR2, OPRK1, OPRD1 | OPRM1 8/4885OGFRL1 307/4885OPRL1 12/4885 |
| US-20150342929-A1 | Mixed ORL1/mu-agonists for the Treatment of Pain | OPRL1, OPRM1, OPRK1 | OPRM1 2/4885OGFRL1 5/4885OPRL1 1/4885 |
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | OPRL1, OPRK1, OPRD1 | OPRM1 5/4885OGFRL1 6/4885OPRL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.