Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14822004 | 0.87 | CYP1A2 (0.44) | CA12CA1CA2CA9HDAC6 | |
| SCHEMBL10042494 | 0.84 | HDAC6 (0.41) | HDAC6HDAC1HDAC2CA14LMNA | |
| SCHEMBL5655019 | 0.81 | HDAC1 (0.44) | CA12CA1CA2CA9HDAC6 | |
| SCHEMBL499027 | 0.81 | SMN1; SMN2 (0.40) | CA12CA1CA2CA9HDAC6 | |
| SCHEMBL5001089 | 0.80 | CA12 (0.55) | CA12CA1CA2CA9HDAC6 | |
| SCHEMBL7456183 | 0.80 | CA14 (0.40) | CA12CA1CA2CA9HDAC6 | |
| SCHEMBL9227134 | 0.79 | HDAC6 (0.46) | HDAC6HDAC1HDAC2CA14TRPV4 | |
| SCHEMBL18758783 | 0.78 | CA12 (0.43) | CA12CA1CA2CA9HDAC6 | |
| SCHEMBL10042493 | 0.78 | HDAC1 (0.35) | HDAC6HDAC1HDAC2 | |
| SCHEMBL15312506 | 0.78 | SMN1; SMN2 (0.38) | CA12CA1CA2CA9HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165275-A1 | Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules | AFFYMAX, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165275-A1 | Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules | AFFYMAX, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8106154-B2 | Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules | AFFYMAX, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-8106154-B2 | Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules | AFFYMAX, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20090048147-A1 | NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES | AFFYMAX, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048147-A1 | NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES | AFFYMAX, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2008095004-A2 | NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES | AFFYMAX, INC. (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165275-A1 | Nitrogen-Based Linkers for Attaching Modifying Groups to Polypeptides and Other Macromolecules | DNPEP, NGLY1, LNPEP | CA12 1276/4885CA1 1155/4885CA2 4362/4885 |
| US-20090048147-A1 | NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES | NGLY1, YWHAZ, HBZ | CA12 1703/4885CA1 1871/4885CA2 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.