Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LDLR | P01130 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29849010 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL10044321 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL15210053 | 0.87 | IDO1 (0.50) | PTGS2PTGS1 | |
| SCHEMBL10044317 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL15207493 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL15208342 | 0.85 | PTGS1 (0.49) | PTGS2PTGS1 | |
| SCHEMBL15209305 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL15207610 | 0.84 | IDO1 (0.39) | — | |
| SCHEMBL15208438 | 0.84 | ALDH1A1 (0.42) | PTGS2 | |
| SCHEMBL15207363 | 0.83 | PTGS2 (0.49) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2636672-B1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO LTD (CN) | 2016-05-18 | — | — | EP | claimed |
| US-20140045901-A2 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2014-02-13 | — | — | US | claimed |
| EP-2636672-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | Beijing Orbiepharm Co., Ltd. (CN) | 2013-09-11 | — | — | EP | claimed |
| US-20130225638-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2013-08-29 | — | — | US | claimed |
| CN-102464652-A | Imidazole derivative, preparation method and application | BEIJING ORBIEPHARM CO LTD | 2012-05-23 | — | — | CN | claimed |
| EP-2636672-B1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO LTD (CN) | 2016-05-18 | — | — | EP | disclosed |
| EP-2636672-B1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO LTD (CN) | 2016-05-18 | — | — | EP | disclosed |
| US-9079876-B2 | Imidazole derivatives and preparation method and use thereof | BEIJING ORBIEPHARM CO., LTD. (CN) | 2015-07-14 | — | — | US | disclosed |
| US-9079876-B2 | Imidazole derivatives and preparation method and use thereof | BEIJING ORBIEPHARM CO., LTD. (CN) | 2015-07-14 | — | — | US | disclosed |
| US-9079876-B2 | Imidazole derivatives and preparation method and use thereof | BEIJING ORBIEPHARM CO., LTD. (CN) | 2015-07-14 | — | — | US | disclosed |
| US-20140045901-A2 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2014-02-13 | — | — | US | disclosed |
| US-20140045901-A2 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2014-02-13 | — | — | US | disclosed |
| EP-2636672-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | Beijing Orbiepharm Co., Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| EP-2636672-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | Beijing Orbiepharm Co., Ltd. (CN) | 2013-09-11 | — | — | EP | disclosed |
| US-20130225638-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2013-08-29 | — | — | US | disclosed |
| US-20130225638-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2013-08-29 | — | — | US | disclosed |
| US-20130225638-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | BEIJING ORBIEPHARM CO., LTD (CN) | 2013-08-29 | — | — | US | disclosed |
| CN-102464652-B | Imidazole derivative and preparation method as well application | BEIJING ORBIEPHARM CO LTD | 2013-08-28 | — | — | CN | disclosed |
| CN-102464652-A | Imidazole derivative, preparation method and application | BEIJING ORBIEPHARM CO LTD | 2012-05-23 | — | — | CN | disclosed |
| WO-2012059001-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | 北京欧博方医药科技有限公司 (CN) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225638-A1 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | PTGIS, PTGS1, PTGS2 | PTGS2 3/4885PTGS1 2/4885ALOX5 41/4885 |
| US-20140045901-A2 | IMIDAZOLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | PTGIS, PTGS1, PTGS2 | PTGS2 3/4885PTGS1 2/4885ALOX5 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.