Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | EBP | Q15125 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15180045 | 0.85 | SIGMAR1 (0.41) | SIGMAR1EBPHRH3LMNAHTR1A | |
| SCHEMBL28928134 | 0.68 | CYP1A2 (0.39) | KDM4EALDH1A1CYP19A1NQO2 | |
| SCHEMBL15672343 | 0.65 | CYP1A2 (0.37) | LMNAKDM4EALDH1A1CYP19A1NQO2 | |
| SCHEMBL13067435 | 0.65 | ALDH1A1 (0.40) | LMNAKDM4EALDH1A1CYP19A1NQO2 | |
| SCHEMBL14963168 | 0.64 | ALDH1A1 (0.41) | LMNAKDM4EALDH1A1CYP19A1NQO2 | |
| SCHEMBL13202682 | 0.64 | HPGD (0.41) | HRH3SLC6A4MAPTKDM4EALDH1A1 | |
| SCHEMBL13828731 | 0.64 | CYP1A2 (0.44) | LMNACD274KDM4EALDH1A1CYP19A1 | |
| SCHEMBL12551006 | 0.62 | TSHR (0.49) | LMNAHTR1AMAPTKDM4EALDH1A1 | |
| SCHEMBL12961532 | 0.62 | SIGMAR1 (0.60) | SIGMAR1EBPTMEM97 | |
| SCHEMBL806010 | 0.61 | GNAI3 (0.41) | SIGMAR1HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052420-A1 | METHOD FOR PREPARING SUBSTITUTED N-(3-AMINO-QUINOXALIN-2-YL)-SULFONAMIDES AND THEIR INTERMEDIATES N-(3-CHLORO-QUINOXALIN-2-YL)SULFONAMIDES | MERCK SERONO S.A. GENEVA (CH) | 2012-04-26 | — | — | WO | disclosed |