Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 11/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.39 |
| ▸ | ULK1 | O75385 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044732 | 0.89 | ULK1 (0.42) | FGFR3KDRGABRA5ULK1AURKA | |
| SCHEMBL10044647 | 0.85 | GABRA5 (0.41) | FGFR3KDRGABRA5ULK1 | |
| SCHEMBL10044780 | 0.85 | FGFR3 (0.42) | FGFR3KDRGABRA5ULK1 | |
| SCHEMBL10044689 | 0.85 | FGFR3 (0.39) | FGFR3KDRGABRA5ULK1 | |
| SCHEMBL10044644 | 0.82 | PRMT7 (0.46) | FGFR3KDR | |
| SCHEMBL10044648 | 0.82 | FGFR3 (0.43) | FGFR3KDRULK1 | |
| SCHEMBL10044773 | 0.82 | PRMT7 (0.46) | FGFR3KDRULK1 | |
| SCHEMBL10044790 | 0.81 | FGFR3 (0.41) | FGFR3KDRULK1 | |
| SCHEMBL10044767 | 0.81 | ROCK2 (0.47) | GABRA5ULK1 | |
| SCHEMBL10044667 | 0.80 | PI4KA (0.42) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221336-A1 | COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-20120157429-A1 | COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2012-06-21 | — | — | US | disclosed |
| US-20100160287-A1 | COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-24 | — | — | US | disclosed |
| WO-2008116139-A2 | N-HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157429-A1 | COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | JAK2, JAK1, JAK3 | FGFR3 574/4885KDR 997/4885GABRA5 2990/4885 |
| US-20100160287-A1 | COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | JAK2, JAK1, JAK3 | FGFR3 574/4885KDR 997/4885GABRA5 2990/4885 |
| US-20140221336-A1 | COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES | JAK2, JAK1, JAK3 | FGFR3 574/4885KDR 997/4885GABRA5 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.