Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 6/20 | 0.46 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 6/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004553 | 1.00 | HTR3A (0.46) | HTR3ATOP2APARP1NR1H2POLB | |
| SCHEMBL1004914 | 0.91 | SMARCA2 (0.43) | HTR3ATOP2APARP1TP53MAPT | |
| SCHEMBL1004487 | 0.91 | SMARCA2 (0.43) | HTR3ATOP2APARP1TP53MAPT | |
| SCHEMBL1004489 | 0.91 | SMARCA2 (0.43) | HTR3ATOP2APARP1TP53MAPT | |
| SCHEMBL1005641 | 0.91 | HTR3A (0.45) | HTR3APARP1POLBMMP13TP53 | |
| SCHEMBL1005642 | 0.91 | HTR3A (0.45) | HTR3APARP1POLBMMP13TP53 | |
| SCHEMBL1005073 | 0.84 | PARP1 (0.44) | HTR3ATOP2APARP1POLBKCNH2 | |
| SCHEMBL1004469 | 0.82 | HTR3A (0.48) | HTR3ATOP2APARP1KCNH2 | |
| SCHEMBL1004355 | 0.82 | HTR3A (0.48) | HTR3ATOP2APARP1KCNH2 | |
| SCHEMBL1005158 | 0.82 | HTR3A (0.48) | HTR3ATOP2APARP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863271-B2 | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | AMR TECHNOLOGY, INC. (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | HTR3E, HTR3C, HTR3A | HTR3A 3/4885TOP2A 323/4885PARP1 1738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.