SCHEMBL10045643

SCHEMBL10045643

O=C1c2cc(-c3cc(-c4ccccc4)cc(-c4ccccc4)c3)ccc2CCc2ccc(-c3cc(-c4ccccc4)cc(-c4ccccc4)c3)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYRO3 Q06418 1/20 0.53
NTRK2 Q16620 1/20 0.53
CLK4 Q9HAZ1 1/20 0.53
DYRK1B Q9Y463 1/20 0.53
L3MBTL1 Q9Y468 2/20 0.52
MEN1 O00255 2/20 0.52
NPC1 O15118 2/20 0.52
MAPT P10636 2/20 0.52
KMT2A Q03164 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
APAF1 O14727 1/20 0.52
LMNA P02545 1/20 0.52
THRB P10828 1/20 0.52
XBP1 P17861 1/20 0.52
PTBP1 P26599 1/20 0.52
HTT P42858 1/20 0.52
RAB9A P51151 1/20 0.52
GALK1 P51570 1/20 0.52
BLM P54132 1/20 0.52
SMAD3 P84022 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10045664 0.96 CLK4 (0.53) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10045704 0.96 TYRO3 (0.56) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10045703 0.96 TYRO3 (0.56) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10045921 0.91 L3MBTL1 (0.67) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10057548 0.89 TYRO3 (0.53) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL22797537 0.86 L3MBTL1 (0.46) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10045920 0.85 TYRO3 (0.41) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10045638 0.85 L3MBTL1 (0.54) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL10045662 0.85 TDP2 (0.49) TYRO3NTRK2CLK4DYRK1BL3MBTL1
SCHEMBL7180348 0.83 MEN1 (0.56) TYRO3NTRK2CLK4DYRK1BL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130112965-A1 ORGANIC LIGHT-EMITTING DEVICE MATERIAL HAVING DIBENZOSUBERONE SKELETON CANON KABUSHIKI KAISHA (JP) 2013-05-09 US disclosed
US-20130112965-A1 ORGANIC LIGHT-EMITTING DEVICE MATERIAL HAVING DIBENZOSUBERONE SKELETON CANON KABUSHIKI KAISHA (JP) 2013-05-09 US disclosed
WO-2012008558-A1 ORGANIC LIGHT-EMITTING DEVICE MATERIAL HAVING DIBENZOSUBERONE SKELETON CANON KABUSHIKI KAISHA (JP) 2012-01-19 WO disclosed