Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13194995 | 0.80 | CYP19A1 (0.52) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL10191716 | 0.80 | CYP19A1 (0.52) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL18193367 | 0.77 | KCNA5 (0.50) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL28814528 | 0.76 | CYP19A1 (0.47) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL21964811 | 0.75 | CYP19A1 (0.41) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL74389 | 0.74 | KIF11 (0.61) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL29583584 | 0.74 | KIF11 (0.61) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL26479501 | 0.74 | CYP19A1 (0.49) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL15979324 | 0.74 | CYP19A1 (0.46) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL10299579 | 0.73 | KCNA5 (0.50) | CYP19A1CYP1A2CYP3A4KCNA5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848275-B1 | KAPPA OPIOID RECEPTOR LIGANDS | RES TRIANGLE INST (US) | 2012-05-02 | — | — | EP | disclosed |