SCHEMBL10046643

SCHEMBL10046643

C=CC(=O)Nc1ccc(C(=O)/C=C/c2ccc(N(C)CCO)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR9 Q9NR96 2/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
MAPT P10636 10/20 0.46
KMT2A Q03164 7/20 0.46
MEN1 O00255 4/20 0.46
ALDH1A1 P00352 4/20 0.46
MAPK1 P28482 2/20 0.46
POLB P06746 2/20 0.46
RECQL P46063 2/20 0.46
USP2 O75604 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
RAB9A P51151 3/20 0.45
NPC1 O15118 2/20 0.45
CASP3 P42574 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP1B1 Q16678 1/20 0.44
SENP8 Q96LD8 1/20 0.44
SENP7 Q9BQF6 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25196445 1.00 TLR9 (0.46) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15216641 0.91 MAPT (0.48) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15218333 0.89 TLR9 (0.46) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15218447 0.88 MAPT (0.55) MAPTKMT2AMEN1MAPK1RAB9A
SCHEMBL18960622 0.87 MAPT (0.61) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL18966872 0.86 TLR9 (0.48) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15218427 0.85 MAPT (0.50) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15218097 0.84 RAB9A (0.50) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15218085 0.83 MAPT (0.52) TLR9CRHBPCRHR2MAPTKMT2A
SCHEMBL15218438 0.83 MAPT (0.56) TLR9CRHBPCRHR2MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-8871976-B2 Chalcone structure fluorescence dye for embryonic stem cell probe NATIONAL UNIVERSITY OF SINGAPORE (SG) 2014-10-28 US disclosed
US-20130224790-A1 Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2013-08-29 US disclosed
WO-2012026886-A1 CHALCONE STRUCTURE FLUORESCENCE DYE FOR EMBRYONIC STEM CELL PROBE NATIONAL UNIVERSITY OF SINGAPORE (SG) 2012-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B TLR9 4430/4885CRHBP 1697/4885CRHR2 3801/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 TLR9 4548/4885CRHBP 1079/4885CRHR2 3714/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 TLR9 4548/4885CRHBP 1079/4885CRHR2 3714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.