Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24161967 | 1.00 | APLNR (0.39) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| Hydrochloric Acid SCHEMBL16039214 | 0.97 | APLNR (0.37) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| SCHEMBL22967525 | 0.83 | ACE (0.39) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| SCHEMBL2389205 | 0.83 | ACE (0.39) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| SCHEMBL31731986 | 0.83 | ACE (0.39) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| SCHEMBL10046703 | 0.83 | ACE (0.39) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| SCHEMBL7658314 | 0.81 | BTK (0.42) | APLNRGABRR1TSHRPMP22GABRP | |
| SCHEMBL24161970 | 0.79 | ALDH1A1 (0.36) | TSHRL3MBTL3ALDH1A1 | |
| SCHEMBL4969805 | 0.78 | APLNR (0.39) | APLNRCYP2C19GABRR1CYP2D6CYP1A2 | |
| SCHEMBL4008610 | 0.77 | LMNA (0.43) | APLNRCYP2C19GABRR1TSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022371-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD (US) | 2012-01-26 | — | — | US | disclosed |
| US-8084610-B2 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD (US) | 2011-12-27 | — | — | US | disclosed |
| US-20080124274-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD | 2008-05-29 | — | — | US | disclosed |
| US-20070286803-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD | 2007-12-13 | — | — | US | disclosed |
| US-20070231256-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES E | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022371-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | CA1, CA14, CA12 | APLNR 373/4885CYP2C19 4802/4885GABRR1 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.