Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1004788 | 1.00 | — | — | |
| Bicarbonate SCHEMBL192950 | 0.94 | — | — | |
| Bicarbonate SCHEMBL541758 | 0.94 | CA4 (0.78) | — | |
| Bicarbonate SCHEMBL1829957 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10909603 | 0.89 | — | — | |
| Bicarbonate SCHEMBL242846 | 0.89 | — | — | |
| Bicarbonate SCHEMBL9059393 | 0.89 | CA4 (0.70) | — | |
| Bicarbonate SCHEMBL28988588 | 0.89 | CA4 (0.70) | — | |
| Bicarbonate SCHEMBL8040237 | 0.89 | — | — | |
| Bicarbonate SCHEMBL14562617 | 0.89 | CA4 (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210171537-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2021-06-10 | — | — | US | disclosed |
| EP-3551626-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2019-10-16 | — | — | EP | disclosed |
| CN-109212903-A | Anti-corrosion agent composition and corrosion-resisting pattern forming method | 信越化学工业株式会社 | 2019-01-15 | — | — | CN | disclosed |
| WO-2018106284-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2018-06-14 | — | — | WO | disclosed |
| CN-104334552-B | Fused heterocyclic compound | 住友化学株式会社 | 2016-08-31 | — | — | CN | disclosed |
| WO-2011014462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
| US-20110021521-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| WO-2000006557-A1 | NOVEL PROCESS FOR MAKING IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |