Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.73 |
| ▸ | MMP12 | P39900 | 16/20 | 0.73 |
| ▸ | MMP9 | P14780 | 15/20 | 0.73 |
| ▸ | MMP13 | P45452 | 12/20 | 0.73 |
| ▸ | MMP14 | P50281 | 12/20 | 0.73 |
| ▸ | MMP8 | P22894 | 11/20 | 0.73 |
| ▸ | MMP16 | P51512 | 11/20 | 0.73 |
| ▸ | MMP3 | P08254 | 9/20 | 0.73 |
| ▸ | MMP1 | P03956 | 7/20 | 0.73 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274484 | 0.95 | MMP2 (0.71) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL13697346 | 0.86 | MMP2 (0.67) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL8228874 | 0.85 | MMP2 (1.00) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL325258 | 0.84 | MMP2 (1.00) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL8843587 | 0.81 | MMP2 (0.64) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL314397 | 0.80 | MMP2 (1.00) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL10181290 | 0.78 | HSD11B1 (0.59) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL8231569 | 0.78 | MMP2 (0.73) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL8843421 | 0.77 | MMP2 (0.64) | MMP2MMP12MMP9MMP13MMP14 | |
| SCHEMBL13210403 | 0.77 | HSD11B1 (0.59) | MMP2MMP12MMP9MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |