Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.71 |
| ▸ | MMP12 | P39900 | 14/20 | 0.71 |
| ▸ | MMP8 | P22894 | 10/20 | 0.71 |
| ▸ | MMP13 | P45452 | 10/20 | 0.71 |
| ▸ | MMP14 | P50281 | 10/20 | 0.71 |
| ▸ | MMP16 | P51512 | 10/20 | 0.71 |
| ▸ | MMP9 | P14780 | 13/20 | 0.66 |
| ▸ | MMP3 | P08254 | 7/20 | 0.66 |
| ▸ | MMP1 | P03956 | 5/20 | 0.66 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10049385 | 0.95 | MMP2 (0.73) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL8843587 | 0.84 | MMP2 (0.64) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL10181290 | 0.82 | HSD11B1 (0.59) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL8843421 | 0.81 | MMP2 (0.64) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL13697346 | 0.81 | MMP2 (0.67) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL13210403 | 0.81 | HSD11B1 (0.59) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL8228783 | 0.80 | MMP2 (1.00) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL8228874 | 0.80 | MMP2 (1.00) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL7266402 | 0.79 | HSD11B1 (0.61) | MMP2MMP12MMP8MMP13MMP14 | |
| SCHEMBL931939 | 0.79 | HTR6 (0.77) | MMP2MMP12MMP8MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302792-B1 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI SA (FR) | 1994-10-26 | — | — | EP | disclosed |
| EP-0302793-B1 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| US-5215988-A | Treating angina, hypertension, arrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-06-01 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4994474-A | Hypotensive agents | SANOFI (FR) | 1991-02-19 | — | — | US | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302793-A2 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | ELF SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |