SCHEMBL1005260

SCHEMBL1005260

Clc1ccc([C]c2ccc(Cl)c(Cl)c2Cl)c(Cl)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.43
MAPK1 P28482 2/20 0.43
AHR P35869 4/20 0.37
TDP1 Q9NUW8 2/20 0.36
CYP2A6 P11509 2/20 0.33
TSHR P16473 1/20 0.31
CYP1A2 P05177 1/20 0.30
NOTUM Q6P988 1/20 0.30
TRPV4 Q9HBA0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18245052 0.78 CYP3A4 (0.40) CYP3A4MAPK1AHRTDP1CYP2A6
SCHEMBL329657 0.78 MAPK1 (0.40) CYP3A4MAPK1AHRTDP1CYP2A6
SCHEMBL2869595 0.78 TRPV4 (0.46) CYP3A4MAPK1TRPV4
SCHEMBL16958929 0.78 CYP3A4 (0.40) CYP3A4MAPK1AHRTDP1CYP2A6
SCHEMBL29368277 0.77 CYP3A4 (0.62) CYP3A4MAPK1AHRTDP1CYP2A6
SCHEMBL348089 0.77 CYP3A4 (0.62) CYP3A4MAPK1AHRTDP1CYP2A6
Methane SCHEMBL23466796 0.73 CYP3A4 (0.59) CYP3A4MAPK1AHRTDP1CYP2A6
SCHEMBL28338848 0.73 CYP3A4 (0.59) CYP3A4MAPK1AHRTDP1CYP2A6
SCHEMBL27259983 0.73 CYP3A4 (0.59) CYP3A4MAPK1AHRTDP1CYP2A6
Ammonia Solution, Strong SCHEMBL28194262 0.73 CYP3A4 (0.59) CYP3A4MAPK1AHRTDP1CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2451869-A1 PHENYLPHOSPHONATE FLAME RETARDANT COMPOSITIONS BASF SE (DE) 2012-05-16 EP disclosed
WO-2011003773-A1 PHENYLPHOSPHONATE FLAME RETARDANT COMPOSITIONS BASF SE (DE) 2011-01-13 WO disclosed