SCHEMBL329657

SCHEMBL329657

O=[C]c1ccc(Cl)c(Cl)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.40
CYP3A4 P08684 2/20 0.40
TDP1 Q9NUW8 2/20 0.38
AHR P35869 3/20 0.34
CYP2A6 P11509 1/20 0.31
CES1 P23141 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL103338 0.89
SCHEMBL103590 0.80 MAPK1 (0.30) MAPK1TDP1
SCHEMBL104540 0.80 CES1 (0.32) MAPK1CYP3A4TDP1CES1
SCHEMBL21201431 0.78 USP2 (0.31) TDP1
SCHEMBL10490638 0.78
SCHEMBL11173801 0.78 AR (0.36) CYP3A4CES1
SCHEMBL9311176 0.78 CYP3A4 (0.31) MAPK1CYP3A4TDP1
SCHEMBL1005260 0.78 CYP3A4 (0.43) MAPK1CYP3A4TDP1AHRCYP2A6
SCHEMBL95210 0.77 TSHR (0.42) CYP3A4TDP1CYP2A6
SCHEMBL9034278 0.75 ALDH1A1 (0.40) MAPK1CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3071602-B1 NANOFIBERS CONTAINING PHOTOCURABLE ESTER DERIVATIVE OF HYALURONIC ACID OR ITS SALT, PHOTOCURED NANOFIBERS, METHOD OF SYNTHESIS THEREOF, PREPARATION CONTAINING PHOTOCURED NANOFIBERS AND USE THEREOF CONTIPRO AS (CZ) 2017-08-23 EP claimed
US-9234087-B2 Preparation for initiating radical reactions UNITED INITIATORS GMBH & CO. KG (DE) 2016-01-12 US claimed
EP-2288652-B1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO KG (DE) 2012-09-19 EP claimed
EP-2130858-B1 Preparations to initiate radical reactions UNITED INITIATORS GMBH & CO KG (DE) 2012-07-25 EP claimed
US-20110272628-A1 Preparation For Initiating Radical Reactions UNITED INITIATORS GMBH (DE) 2011-11-10 US claimed
JP-4709386-B2 2011-06-22 JP claimed
JP-4709387-B2 2011-06-22 JP claimed
EP-2288652-A1 PREPARATION FOR INITIATING RADICAL REACTIONS United Initiators GmbH & Co. KG (DE) 2011-03-02 EP claimed
EP-1150676-B1 ACYL DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF SOUTHERN RES INST (US) 2010-08-11 EP claimed
WO-2009146916-A1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO. KG (DE) 2009-12-10 WO claimed
EP-1150676-A4 ACYL DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF SOUTHERN RES INST (US) 2003-01-08 EP claimed
US-6391893-B1 ANTICANCER AGENTS SOUTHERN RESEARCH INSTITUTE 2002-05-21 US claimed
US-6376518-B1 ANTICARCINOGENIC AGENTS; SIDE EFFECT REDUCTION SOUTHERN RESEARCH INSTITUTE 2002-04-23 US claimed
EP-1150676-A1 ACYL DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF Southern Research Institute (US) 2001-11-07 EP claimed
EP-1143970-A1 PYRIDINE COMPOUNDS, USE AND PREPARATION THEREOF Southern Research Institute (US) 2001-10-17 EP claimed
WO-2000043010-A1 ACYL DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF SOUTHERN RESEARCH INSTITUTE (US) 2000-07-27 WO claimed
WO-2000043009-A1 PYRIDINE COMPOUNDS, USE AND PREPARATION THEREOF SOUTHERN RESEARCH INSTITUTE (US) 2000-07-27 WO claimed
EP-0596015-B1 SUBSTITUTED BETA-LACTAM COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS AND PROCESSES FOR THE PREPARATION THEREOF SCHERING CORP (US) 1997-10-01 EP claimed
US-5192767-A Nonphytotoxic BASF AKTIENGESELLSCHAFT (DE) 1993-03-09 US claimed
US-4952585-A Castanospermine esters in the inhibition of tumor metastasis MERRELL DOW PHARMACEUTICALS INC. (US) 1990-08-28 US claimed