Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824473 | 0.61 | GAA (0.35) | GSK3AGSK3BGAAHTR3EHTR3B | |
| SCHEMBL1328455 | 0.61 | GAA (0.35) | GSK3AGSK3BGAAHTR3EHTR3B | |
| SCHEMBL11731597 | 0.58 | CFTR (0.38) | GSK3AGSK3BGAAALDH1A1NPSR1 | |
| SCHEMBL1029480 | 0.56 | MEN1 (0.32) | GSK3AGSK3BGAAALDH1A1NPSR1 | |
| SCHEMBL9360920 | 0.54 | — | — | |
| SCHEMBL447261 | 0.53 | GSK3A (1.00) | GSK3AGSK3BGAAALDH1A1 | |
| SCHEMBL5012600 | 0.53 | GAA (0.52) | GSK3AGSK3BGAAALDH1A1NPSR1 | |
| SCHEMBL1007068 | 0.51 | KDM4E (0.35) | GSK3AGSK3BGAANPSR1HTR3E | |
| SCHEMBL11953121 | 0.51 | KDM4E (0.46) | GSK3AGSK3BGAAALDH1A1 | |
| SCHEMBL11861466 | 0.51 | KDM4E (0.67) | GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056880-A | Novel pyrido [2, 3-f ] [1, 4] thiazepines and pyrido [3, 2-b ] [1, 5] benzothiazepines | ORTHO PHARMA CORP (US) | 1991-12-11 | — | — | CN | claimed |
| CN-1989106-B | N-hydroxyamide derivatives and their use | MERCK SERONO SA | 2013-12-04 | — | — | CN | disclosed |
| US-8247437-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-08-21 | — | — | US | disclosed |
| US-8198280-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-06-12 | — | — | US | disclosed |
| CN-101208320-B | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA | 2012-01-11 | — | — | CN | disclosed |
| US-20110281891-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2011-11-17 | — | — | US | disclosed |
| US-20110263628-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-10-27 | — | — | US | disclosed |
| US-8008302-B2 | ((2S,3S) N,2-dihydroxy-5-methyl-3-{[4-(2-pyridinyl)-1-piperazinyl]carbonyl}hexanamide; for treatment and/or prevention of disorders related to autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, stroke, cancer, pre-term labor, endometriosis | MERCK SERONO SA (CH) | 2011-08-30 | — | — | US | disclosed |
| EP-1951687-B1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2011-08-24 | — | — | EP | disclosed |
| US-7998964-B2 | hydroxy((2S)-2-{[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl}-4-methylpentyl)formamide ; for treatment and/or prevention of disorders related to autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative disorders, stroke, cancer, pre-term labor, endometriosis | MERCK SERONO S.A. (CH) | 2011-08-16 | — | — | US | disclosed |
| EP-1951687-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Laboratoires Serono SA (CH) | 2008-08-06 | — | — | EP | disclosed |
| CN-101208320-A | N-hydroxyamide derivatives and use thereof | APPLIED RESEARCH SYSTEMS (CH) | 2008-06-25 | — | — | CN | disclosed |
| US-20080090838-A1 | N-Hydroxyamide Derivatives and Use Thereof | LABORATOIRES SERONO S.A. (CH) | 2008-04-17 | — | — | US | disclosed |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2008-01-24 | — | — | US | disclosed |
| EP-1844032-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2007-10-17 | — | — | EP | disclosed |
| CN-1989106-A | N-hydroxyamide derivatives and their use | APPLIED RESEARCH SYSTEMS (AN) | 2007-06-27 | — | — | CN | disclosed |
| WO-2007060132-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2007-05-31 | — | — | WO | disclosed |
| EP-1771421-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006079653-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-08-03 | — | — | WO | disclosed |
| WO-2006010751-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090838-A1 | N-Hydroxyamide Derivatives and Use Thereof | HNMT, ALOX5, HCAR2 | GSK3A 1671/4885GSK3B 1835/4885GAA 1950/4885 |
| US-20110263628-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | HNMT, HCAR2, HPGD | GSK3A 1422/4885GSK3B 1585/4885GAA 2031/4885 |
| US-20110281891-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | HNMT, HCAR2, HPGD | GSK3A 1422/4885GSK3B 1585/4885GAA 2031/4885 |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | HCAR2, HNMT, HPGD | GSK3A 1566/4885GSK3B 1764/4885GAA 2072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.