SCHEMBL10053553

SCHEMBL10053553

COc1ccc(N(c2ccc(CO)cc2)c2cccc3cc4ccccc4cc23)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 1/20 0.38
TOP2B Q02880 1/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
KEAP1 Q14145 2/20 0.37
NFE2L2 Q16236 2/20 0.37
GRM2 Q14416 1/20 0.37
LTA4H P09960 2/20 0.36
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15478214 0.89 CYP1A2 (0.43) ALDH1A1KDM4EKEAP1NFE2L2TUBB4A
SCHEMBL12442847 0.83 MEN1 (0.41) TOP2ATOP2BMEN1KMT2AALDH1A1
SCHEMBL14569517 0.82 NQO2 (0.41) MEN1KMT2AKDM4ENFE2L2TUBB4A
SCHEMBL9971802 0.81 TOP2A (0.40) TOP2ATOP2BMEN1KMT2AALDH1A1
SCHEMBL10062456 0.81 CYP1A2 (0.46) MEN1KMT2AALDH1A1KDM4ETSHR
SCHEMBL12238160 0.79 LTA4H (0.41) TOP2ATOP2BMEN1KMT2AKDM4E
SCHEMBL14003987 0.79 TUBB4A (0.45) MEN1KMT2AALDH1A1KDM4ELTA4H
SCHEMBL10062039 0.79 ABCB1 (0.42) ALDH1A1KEAP1LTA4H
SCHEMBL18268265 0.78 LTA4H (0.46) TOP2ATOP2BMEN1KMT2AALDH1A1
SCHEMBL18268266 0.77 LTA4H (0.52) MEN1KMT2AKDM4ELTA4HTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8652717-B2 Image bearing member and image forming method, image forming apparatus, and process cartridge using the same RICOH COMPANY, LTD. (JP) 2014-02-18 US disclosed
US-20120163860-A1 IMAGE BEARING MEMBER AND IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE USING THE SAME RICOH COMPANY, LTD. (JP) 2012-06-28 US disclosed