Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.38 |
| ▸ | SCD | O00767 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1006391 | 0.82 | GPR119 (0.43) | GPR119KCNH2 | |
| SCHEMBL12239176 | 0.82 | CSNK2A1 (0.45) | GPR119SCD | |
| SCHEMBL1006510 | 0.81 | GPR119 (0.41) | GPR119SCDHDAC3PDE5AHDAC1 | |
| SCHEMBL1003971 | 0.80 | SCD (0.46) | GPR119SCDKCNH2 | |
| SCHEMBL1006506 | 0.79 | GPR119 (0.47) | GPR119KCNH2 | |
| SCHEMBL1005451 | 0.77 | PDE4D (0.45) | GPR119 | |
| SCHEMBL1006762 | 0.77 | GPR119 (0.45) | GPR119 | |
| SCHEMBL1005428 | 0.77 | SCD (0.47) | GPR119SCDKCNH2 | |
| SCHEMBL2548234 | 0.77 | GPR119 (0.40) | GPR119SCDHDAC3PDE5AHDAC1 | |
| SCHEMBL12239188 | 0.73 | GPR119 (0.42) | GPR119SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271619-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126535-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-10-15 | — | — | WO | disclosed |