Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.45 |
| ▸ | FPR2 | P25090 | 7/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1006391 | 0.92 | GPR119 (0.43) | GPR119FPR2PROKR1MMP13 | |
| SCHEMBL1006506 | 0.91 | GPR119 (0.47) | GPR119FPR2PROKR1 | |
| SCHEMBL12239176 | 0.85 | CSNK2A1 (0.45) | GPR119FPR2PROKR1 | |
| SCHEMBL1006510 | 0.83 | GPR119 (0.41) | GPR119FPR2PROKR1 | |
| SCHEMBL1005839 | 0.82 | GPR119 (0.44) | GPR119 | |
| SCHEMBL1006266 | 0.80 | GPR119 (0.43) | GPR119 | |
| SCHEMBL12239178 | 0.80 | PROKR1 (0.39) | FPR2PROKR1SMN1; SMN2MMP13 | |
| SCHEMBL1005451 | 0.80 | PDE4D (0.45) | GPR119 | |
| SCHEMBL1005428 | 0.80 | SCD (0.47) | GPR119FPR2PROKR1 | |
| SCHEMBL1003971 | 0.79 | SCD (0.46) | GPR119FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271619-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126535-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-10-15 | — | — | WO | disclosed |