SCHEMBL12239176

SCHEMBL12239176

CCc1cnc(N2CCC(Oc3ccc(CC4CCCCC4)cc3Cl)CC2)nc1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 2/20 0.45
SCD O00767 5/20 0.43
GPR119 Q8TDV5 10/20 0.43
SCN1A P35498 1/20 0.39
SCN8A Q9UQD0 1/20 0.39
FPR2 P25090 1/20 0.36
PROKR1 Q8TCW9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1006506 0.87 GPR119 (0.47) GPR119FPR2PROKR1
SCHEMBL1006510 0.87 GPR119 (0.41) SCDGPR119FPR2PROKR1
SCHEMBL1005428 0.86 SCD (0.47) CSNK2A1SCDGPR119FPR2PROKR1
SCHEMBL12239172 0.86 SMN1; SMN2 (0.43) CSNK2A1SCDGPR119SCN1ASCN8A
SCHEMBL1003971 0.85 SCD (0.46) CSNK2A1SCDGPR119FPR2PROKR1
SCHEMBL1006762 0.85 GPR119 (0.45) GPR119FPR2PROKR1
SCHEMBL12239187 0.84 CSNK2A1 (0.45) CSNK2A1SCDGPR119
SCHEMBL1005451 0.83 PDE4D (0.45) GPR119
SCHEMBL12239173 0.83 GPR119 (0.48) GPR119
SCHEMBL12239182 0.83 ALDH1A1 (0.51) CSNK2A1SCDGPR119SCN1ASCN8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110263557-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263557-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY GPR119, GPR55, NR1H2 CSNK2A1 988/4885SCD 1145/4885GPR119 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.