Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | RAD52 | P43351 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | GUSB | P08236 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13692664 | 0.82 | KMT2A (0.78) | KMT2AKDM4EMEN1RAD52TP53 | |
| SCHEMBL20605594 | 0.81 | MAPT (0.56) | KMT2AKDM4EMEN1RAD52NPC1 | |
| SCHEMBL20605588 | 0.79 | MEN1 (0.51) | KMT2AKDM4EMEN1RAD52MAPT | |
| Hydrochloric Acid SCHEMBL2460425 | 0.78 | KMT2A (0.73) | KMT2AKDM4EMEN1RAD52TP53 | |
| SCHEMBL13692649 | 0.76 | KMT2A (0.71) | KMT2AKDM4EMEN1RAD52TP53 | |
| SCHEMBL20605535 | 0.76 | MEN1 (0.53) | KMT2AKDM4EMEN1RAD52TP53 | |
| SCHEMBL21346881 | 0.74 | TP53 (0.71) | KMT2AKDM4EMEN1RAD52TP53 | |
| SCHEMBL9709748 | 0.74 | KMT2A (0.56) | KMT2AKDM4EMEN1RAD52TP53 | |
| SCHEMBL20605450 | 0.74 | KMT2A (0.49) | KMT2AKDM4EMEN1GAASMN1; SMN2 | |
| SCHEMBL6608655 | 0.73 | HTT (0.59) | KMT2AKDM4EMEN1RAD52NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853920-B1 | FLUORESCENCE POLARIZATION ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY | SIRTRIS PHARMACEUTICALS INC (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100168084-A1 | Therapeutic compounds and related methods of use | ELIXIR PHARMACEUTICALS, INC. | 2010-07-01 | — | — | US | disclosed |
| US-20100168084-A1 | Therapeutic compounds and related methods of use | ELIXIR PHARMACEUTICALS, INC. | 2010-07-01 | — | — | US | disclosed |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-20080293081-A1 | Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293081-A1 | Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168084-A1 | Therapeutic compounds and related methods of use | EP300, KAT2A, KAT6B | KMT2A 422/4885KDM4E 1406/4885MEN1 2682/4885 |
| US-20090069301-A1 | Acridine and Quinoline Derivatives as Sirtuin Modulators | SIRT1, SIRT3, SIRT2 | KMT2A 1098/4885KDM4E 2555/4885MEN1 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.