Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 4/20 | 0.61 |
| ▸ | BCHE | P06276 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13253516 | 0.83 | MEN1 (0.64) | HTTGAAMAPTKMT2AMEN1 | |
| SCHEMBL10061810 | 0.81 | POLB (0.69) | APPACHEBCHEHTTGAA | |
| SCHEMBL9208663 | 0.79 | HTT (0.74) | APPACHEBCHEHTTGAA | |
| SCHEMBL10062368 | 0.79 | MAPT (0.74) | APPACHEBCHEGAAMAPT | |
| SCHEMBL8473136 | 0.78 | HTT (0.69) | ACHEBCHEHTTGAAMAPT | |
| SCHEMBL8472225 | 0.77 | HTT (0.71) | ACHEBCHEHTTGAAMAPT | |
| SCHEMBL8476129 | 0.76 | HTT (0.73) | ACHEBCHEHTTGAAMAPT | |
| SCHEMBL9821200 | 0.75 | BCHE (0.63) | APPACHEBCHEHTTGAA | |
| SCHEMBL8474173 | 0.75 | BCHE (0.66) | APPACHEBCHEHTTGAA | |
| SCHEMBL10061811 | 0.75 | MEN1 (0.69) | APPACHEBCHEHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853920-B1 | FLUORESCENCE POLARIZATION ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY | SIRTRIS PHARMACEUTICALS INC (US) | 2012-02-01 | — | — | EP | disclosed |