Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 5/20 | 0.44 |
| ▸ | TTK | P33981 | 3/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 5/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10063135 | 0.84 | EPHX2 (0.57) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10063136 | 0.80 | MCL1 (0.57) | ITKTTKMCL1AURKBINCENP | |
| SCHEMBL10063143 | 0.79 | ITK (0.50) | ITKTTKMCL1AURKBINCENP | |
| SCHEMBL10063164 | 0.78 | ITK (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10063171 | 0.78 | ITK (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10063183 | 0.78 | ITK (0.51) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10063108 | 0.78 | GPR142 (0.57) | ITKTTKMCL1AURKBINCENP | |
| SCHEMBL10063248 | 0.76 | LMNA (0.56) | TTKAURKBINCENPP2RX7 | |
| SCHEMBL10063122 | 0.75 | ROCK2 (0.59) | ITKTTKMCL1AURKBINCENP | |
| SCHEMBL10063130 | 0.73 | HPGD (0.55) | TTKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |