SCHEMBL10063754

SCHEMBL10063754

CCC(=O)NC(C=O)Cc1c[nH]c2ccccc12

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.71
ALOX15 P16050 1/20 0.54
KDM4E B2RXH2 3/20 0.53
MAPT P10636 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
POLB P06746 2/20 0.53
APAF1 O14727 1/20 0.53
RECQL P46063 1/20 0.53
CASP1 P29466 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.51
ACE P12821 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
LMNA P02545 1/20 0.50
MPO P05164 1/20 0.50
TSHR P16473 1/20 0.50
BLM P54132 1/20 0.50
PMP22 Q01453 1/20 0.50
HIF1A Q16665 1/20 0.50
ALDH1A1 P00352 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12384232 0.91 CTSL (0.73) CTSLALOX15KDM4EMAPTL3MBTL1
SCHEMBL20204707 0.91 CTSL (0.70) CTSLALOX15KDM4ECASP1ACE
SCHEMBL20204703 0.91 CTSL (0.70) CTSLALOX15KDM4ECASP1ACE
SCHEMBL26334901 0.88 CTSL (0.65) CTSLALOX15KDM4EMAPTL3MBTL1
SCHEMBL18232014 0.88 CTSL (0.65) CTSLALOX15KDM4EMAPTL3MBTL1
SCHEMBL10890916 0.87 CTSL (0.68) CTSLALOX15KDM4EL3MBTL1MEN1
SCHEMBL7123258 0.87 CTSL (0.71) CTSLALOX15KDM4EMAPTL3MBTL1
SCHEMBL13254023 0.87 CTSL (0.71) CTSLALOX15KDM4EMAPTL3MBTL1
SCHEMBL18232271 0.87 CTSL (0.64) CTSLALOX15KDM4EMAPTL3MBTL1
SCHEMBL10893970 0.86 CTSL (0.67) CTSLALOX15KDM4EL3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120041079-A1 DEXTRAN FUNCTIONALIZED BY HYDROPHOBIC AMINO ACIDS ADOCIA (FR) 2012-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120041079-A1 DEXTRAN FUNCTIONALIZED BY HYDROPHOBIC AMINO ACIDS SLC43A1, SLC1A5, DAO CTSL 2635/4885ALOX15 1838/4885KDM4E 2138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.