Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.44 |
| ▸ | TUBB | P07437 | 5/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Steganacin SCHEMBL66054 | 1.00 | LMNA (0.57) | LMNACYP3A4POLBHTTTUBB4A | |
| Steganacin SCHEMBL14138211 | 1.00 | LMNA (0.57) | LMNACYP3A4POLBHTTTUBB4A | |
| SCHEMBL19050768 | 0.91 | CYP3A4 (0.53) | LMNACYP3A4POLBHTTTUBB4A | |
| Steganacin SCHEMBL8044045 | 0.89 | CYP3A4 (0.48) | LMNACYP3A4POLBHTTTUBB4A | |
| SCHEMBL5014622 | 0.86 | CYP3A4 (0.54) | LMNACYP3A4POLBTUBB4ATUBB | |
| SCHEMBL14097830 | 0.86 | CYP3A4 (0.54) | LMNACYP3A4POLBTUBB4ATUBB | |
| SCHEMBL9951919 | 0.77 | GSK3B (0.47) | LMNACYP3A4POLBTUBB4ATUBB | |
| Stegane SCHEMBL5014561 | 0.76 | TUBB4A (0.53) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| Picrostegane SCHEMBL14097820 | 0.76 | TUBB4A (0.53) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4276054 | 0.73 | LMNA (1.00) | LMNACYP3A4HTTTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914733-B2 | Biisoquinoline compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-03-13 | — | — | US | disclosed |
| US-20170183349-A1 | BIISOQUINOLINE COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2017-06-29 | — | — | US | disclosed |
| WO-2012059568-A1 | NOVEL WATER-SOLUBLE INDOLOBENZAZEPINE MOLECULES DEMONSTRATING ANTIMITOTIC, ANTIVASCULAR, AND ANTITUMOR ACTIVITIES IN VIVO | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183349-A1 | BIISOQUINOLINE COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | LMNA 979/4885CYP3A4 4137/4885POLB 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.