SCHEMBL10065062

SCHEMBL10065062

CC(Oc1cccc(C(C)(C)C)c1)C(=O)Nc1ccc(C(C)CC(=O)O)cc1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.62
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
RXFP1 Q9HBX9 2/20 0.48
TSHR P16473 1/20 0.47
POLB P06746 1/20 0.47
ATM Q13315 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
ALDH1A1 P00352 2/20 0.45
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
NR1H4 Q96RI1 1/20 0.42
HTT P42858 1/20 0.42
ITGB1 P05556 1/20 0.41
ITGA4 P13612 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10064818 0.90 FFAR1 (0.53) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL2753758 0.89 FFAR1 (0.59) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL10065685 0.86 KMT2A (0.64) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL232545 0.86 FFAR1 (0.70) FFAR1TSHR
SCHEMBL3162742 0.85 KMT2A (0.51) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL10064814 0.85 KMT2A (0.51) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL10064815 0.84 KMT2A (0.64) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL15468351 0.83 FFAR1 (0.57) FFAR1KMT2AMEN1RXFP1TSHR
SCHEMBL15692433 0.82 FFAR1 (0.47) FFAR1KMT2AMEN1RXFP1ATM
SCHEMBL10064976 0.81 MEN1 (0.47) FFAR1KMT2AMEN1RXFP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8648038-B2 (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments SANOFI (FR) 2014-02-11 US disclosed
WO-2012004269-A1 (2-ARYLOXY-ACETYLAMINO)-PHENYL-PROPIONIC ACID DERIVATIVES, METHOD FOR PRODUCING SAME AND USE THEREOF AS PHARMACEUTICALS SANOFI (FR) 2012-01-12 WO disclosed
US-20120004167-A1 (2-ARYLOXYACETYLAMINO) PHENYLPROPIONIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS SANOFI (FR) 2012-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004167-A1 (2-ARYLOXYACETYLAMINO) PHENYLPROPIONIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS GPR119, DPP9, DPP7 FFAR1 96/4885KMT2A 3285/4885MEN1 2368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.