Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 5/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10065832 | 0.88 | LMNA (0.57) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL15217613 | 0.80 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2ALDH1A1PRMT5WDR77 | |
| SCHEMBL16561506 | 0.75 | LMNA (0.48) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL18265861 | 0.75 | LMNA (0.48) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL30151141 | 0.73 | LMNA (1.00) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5717747 | 0.73 | LMNA (1.00) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL19199613 | 0.73 | LMNA (0.66) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL360658 | 0.73 | LMNA (0.53) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL10065472 | 0.71 | LMNA (0.54) | LMNAKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL15217609 | 0.70 | SMN1; SMN2 (0.45) | LMNAPOLBSMN1; SMN2ALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170319584-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-09 | — | — | US | disclosed |
| US-20170216291-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2017-08-03 | — | — | US | disclosed |
| EP-3192796-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2017-07-19 | — | — | EP | disclosed |
| US-9650383-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-05-16 | — | — | US | disclosed |
| EP-2593456-B1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | UNIV COLUMBIA (US) | 2016-11-30 | — | — | EP | disclosed |
| US-20150072989-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-03-12 | — | — | US | disclosed |
| WO-2012009553-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216291-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | ALDOA, AKR1B1, AKR1C2 | LMNA 1361/4885KDM4E 1917/4885POLB 1462/4885 |
| US-20170319584-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | ALDOA, AKR1B1, AKR1C2 | LMNA 1361/4885KDM4E 1917/4885POLB 1462/4885 |
| US-20150072989-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | ALDOA, AKR1B1, AKR1C2 | LMNA 1361/4885KDM4E 1917/4885POLB 1462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.