Sugi Predict

Sugi Predict / Compounds / SCHEMBL360658

SCHEMBL360658

SCHEMBL360658

O=C(O)Cc1n[nH]c(=O)c2nccnc12

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.53
▸ GABRR1 P24046 1/20 0.39
▸ PARP1 P09874 6/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ THRA P10827 3/20 0.34
▸ THRB P10828 3/20 0.34
▸ EGLN1 Q9GZT9 1/20 0.34
▸ TSHR P16473 1/20 0.33
▸ AR P10275 1/20 0.33
▸ AGBL2 Q5U5Z8 1/20 0.33
▸ CYP2C19 P33261 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18265861 0.81 LMNA (0.48) LMNAGABRR1ALDH1A1KDM4EPOLB
SCHEMBL16561506 0.81 LMNA (0.48) LMNAGABRR1ALDH1A1KDM4EPOLB
SCHEMBL19575386 0.73 LMNA (0.57) LMNAGABRR1PARP1ALDH1A1KDM4E
SCHEMBL10065832 0.73 LMNA (0.57) LMNAPARP1ALDH1A1KDM4EPOLB
SCHEMBL10065833 0.73 LMNA (0.57) LMNAPARP1ALDH1A1KDM4EPOLB
SCHEMBL10065472 0.73 LMNA (0.54) LMNAGABRR1PARP1ALDH1A1KDM4E
SCHEMBL5717747 0.69 LMNA (1.00) LMNAPARP1ALDH1A1KDM4EPOLB
SCHEMBL19199613 0.69 LMNA (0.66) LMNAGABRR1PARP1ALDH1A1KDM4E
SCHEMBL30151141 0.69 LMNA (1.00) LMNAPARP1ALDH1A1KDM4EPOLB
SCHEMBL17455475 0.66 PDPK1 (0.53) PARP1ALDH1A1KDM4ESMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190201400-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-07-04 — — US disclosed
US-20170319584-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-11-09 — — US disclosed
US-20170216291-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2017-08-03 — — US disclosed
US-20170216292-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-08-03 — — US disclosed
EP-3192796-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF The Trustees of Columbia University in the City of New York (US) 2017-07-19 — — EP disclosed
US-9650383-B2 Aldose reductase inhibitors and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-05-16 — — US disclosed
EP-2593456-B1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF UNIV COLUMBIA (US) 2016-11-30 — — EP disclosed
EP-2945934-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF The Trustees of Columbia University in the City of New York (US) 2015-11-25 — — EP disclosed
US-20150072989-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-03-12 — — US disclosed
US-8916563-B2 Aldose reductase inhibitors and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-12-23 — — US disclosed
WO-2014113380-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-07-24 — — WO disclosed
US-20130225592-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2013-08-29 — — US disclosed
EP-2593456-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF The Trustees of Columbia University in the City of New York (US) 2013-05-22 — — EP disclosed
WO-2012009553-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-01-19 — — WO disclosed
WO-2012009553-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-01-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170216291-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF ALDOA, AKR1B1, AKR1C2 LMNA 1361/4885GABRR1 3471/4885PARP1 889/4885
US-20170319584-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF ALDOA, AKR1B1, AKR1C2 LMNA 1361/4885GABRR1 3471/4885PARP1 889/4885
US-20170216292-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF ALDOA, AKR1B1, AKR1C2 LMNA 1361/4885GABRR1 3471/4885PARP1 889/4885
US-20150072989-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF ALDOA, AKR1B1, AKR1C2 LMNA 1361/4885GABRR1 3471/4885PARP1 889/4885
US-20130225592-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF ALDOA, AKR1B1, AKR1C2 LMNA 1361/4885GABRR1 3471/4885PARP1 889/4885
US-20190201400-A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF ALDOA, AKR1B1, AKR1C2 LMNA 1361/4885GABRR1 3471/4885PARP1 889/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.