Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312643 | 0.87 | JAK2 (0.45) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL312092 | 0.82 | SLC6A2 (0.61) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL4309350 | 0.77 | MEN1 (0.67) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL4239118 | 0.77 | GPR119 (0.56) | JAK2JAK1MEN1KMT2AGPR119 | |
| SCHEMBL312862 | 0.75 | SLC6A2 (0.51) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL4240592 | 0.75 | JAK2 (0.52) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL4306735 | 0.74 | KMT2A (0.57) | JAK2JAK1MEN1KMT2AGPR119 | |
| SCHEMBL28790065 | 0.74 | SLC6A2 (0.50) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL4240396 | 0.74 | ALDH1A1 (0.53) | JAK2JAK1MEN1KMT2AGPR119 | |
| SCHEMBL312781 | 0.74 | SLC6A2 (0.51) | MEN1KMT2APGRCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268631-A1 | AMINOPIPERIDINYL DERIVATIVES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009118254-A1 | AMINOPIPERIDINYL DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-01 | — | — | WO | disclosed |