Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312862 | 0.95 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL312004 | 0.85 | HTR6 (0.51) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL27802769 | 0.81 | JAK2 (0.44) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL312092 | 0.81 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL312519 | 0.80 | JAK2 (0.45) | SLC6A2SLC6A4SLC6A3JAK2JAK1 | |
| SCHEMBL4309350 | 0.80 | MEN1 (0.67) | JAK2JAK1MEN1KMT2APGR | |
| SCHEMBL4239118 | 0.79 | GPR119 (0.56) | JAK2JAK1MEN1KMT2AGPR119 | |
| SCHEMBL3049915 | 0.77 | MEN1 (0.48) | MEN1KMT2AGPR119 | |
| SCHEMBL4306735 | 0.76 | KMT2A (0.57) | JAK2JAK1MEN1KMT2AGPR119 | |
| SCHEMBL4240396 | 0.76 | ALDH1A1 (0.53) | JAK2JAK1MEN1KMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101977904-A | Aminopiperidinyl derivatives and uses thereof | HOFFMANN LA ROCHE | 2011-02-16 | — | — | CN | disclosed |