Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10022478 | 0.87 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022480 | 0.87 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022468 | 0.87 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022581 | 0.85 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022600 | 0.82 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10066563 | 0.81 | ROCK2 (0.77) | ROCK2TP53MAPT | |
| SCHEMBL10022460 | 0.81 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022549 | 0.79 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10066598 | 0.78 | ENPP2 (0.67) | ROCK2 | |
| SCHEMBL10066189 | 0.77 | ROCK2 (0.78) | ROCK2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590950-B1 | N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL)BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-15 | — | — | EP | disclosed |
| WO-2012006203-A1 | N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |