Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.59 |
| ▸ | GRK2 | P25098 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10066414 | 0.78 | ROCK2 (0.77) | ROCK2 | |
| SCHEMBL12790089 | 0.77 | HPGD (0.69) | HPGDHDAC1 | |
| SCHEMBL10022480 | 0.76 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022478 | 0.76 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10022479 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL2555278 | 0.75 | HPGD (0.72) | HPGDIDEMAPK1MAPK10HDAC3 | |
| SCHEMBL11114421 | 0.74 | HPGD (0.67) | HPGDIDEMAPK1MAPK10HDAC3 | |
| SCHEMBL17175809 | 0.74 | IRAK4 (0.69) | ROCK2HPGDMAPK1HDAC1 | |
| SCHEMBL6202834 | 0.73 | HPGD (0.64) | HPGDIDEMAPK1MAPK10HDAC1 | |
| SCHEMBL14368134 | 0.73 | HPGD (0.54) | ENPP2ROCK2GRK2HPGDHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006203-A1 | N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |