Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857303 | 0.88 | HPGD (0.86) | HPGDLMNAMAPTMEN1KMT2A | |
| SCHEMBL168519 | 0.86 | HTR2B (0.66) | HPGDHTR2BLMNAMAPTMEN1 | |
| SCHEMBL27768683 | 0.85 | HPGD (0.68) | HPGDLMNAMAPTMEN1KMT2A | |
| SCHEMBL1785268 | 0.84 | HTR2B (0.59) | HPGDHTR2BLMNAMAPTMEN1 | |
| SCHEMBL657641 | 0.84 | ALDH1A1 (0.70) | HPGDLMNAMAPTMEN1KMT2A | |
| SCHEMBL999473 | 0.83 | HDAC1 (0.69) | HPGDHTR2BLMNAMEN1KMT2A | |
| SCHEMBL10334420 | 0.83 | ALDH1A1 (0.73) | HPGDHTR2BCYP2C19ACHEALDH1A1 | |
| SCHEMBL16310305 | 0.83 | TLR7 (0.57) | HTR2BLMNACYP2C19ACHEALDH1A1 | |
| SCHEMBL1249544 | 0.83 | RAB9A (0.66) | HTR2BLMNAMAPTMEN1KMT2A | |
| SCHEMBL31350948 | 0.82 | HDAC6 (0.70) | LMNAMAPTMAPK1CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |
| US-4571402-A | Anti-bronchoconstriction 2-(4'-pyridinyl)-thiazole derivatives, composition, and method of use therefor | SCHERING CORPORATION (US) | 1986-02-18 | — | — | US | claimed |
| US-4528291-A | 2-(4'-Pyridinyl)-thiazole compounds and their use in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-07-09 | — | — | US | claimed |
| EP-0097323-A2 | 2-(4-Pyridyl)-thiazole derivatives | SCHERING CORPORATION (US) | 1984-01-04 | — | — | EP | claimed |
| WO-2025003987-A1 | NOVEL CARBOXAMIDE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 동화약품주식회사 | 2025-01-02 | — | — | WO | disclosed |
| CN-104837844-B | Pyrazole substituted imidazopiperazines as casein kinase 1D/E inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| US-4571402-A | Anti-bronchoconstriction 2-(4'-pyridinyl)-thiazole derivatives, composition, and method of use therefor | SCHERING CORPORATION (US) | 1986-02-18 | — | — | US | disclosed |
| US-4528291-A | 2-(4'-Pyridinyl)-thiazole compounds and their use in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-07-09 | — | — | US | disclosed |
| EP-0097323-A2 | 2-(4-Pyridyl)-thiazole derivatives | SCHERING CORPORATION (US) | 1984-01-04 | — | — | EP | disclosed |